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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Is Lack of Sleep Capable of Inducing DNA Damage in Aged Skin?

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Author(s):
Kahan, V. [1] ; Ribeiro, D. A. [2] ; Egydio, F. [1] ; Barros, L. A. [1] ; Tomimori, J. [3] ; Tufik, S. [1] ; Andersen, M. L. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biociencias, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Dermatol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SKIN PHARMACOLOGY AND PHYSIOLOGY; v. 27, n. 3, p. 127-131, 2014.
Web of Science Citations: 4
Abstract

Skin naturally changes with age, becoming more fragile. Various stimuli can alter skin integrity. The aim of this study was to evaluate whether sleep deprivation affects the integrity of DNA in skin and exacerbates the effects of aging. Fifteen-month old female Hairless mice underwent 72 h of paradoxical sleep deprivation or 15 days of chronic sleep restriction. Punch biopsies of the skin were taken to evaluate DNA damage by single cell gel (comet) assay. Neither paradoxical sleep deprivation nor sleep restriction increased genetic damage, measured by tail movement and tail intensity values. Taken together, the findings are consistent with the notion that aging overrides the effect of sleep loss on the genetic damage in elderly mice. (C) 2014 S. Karger AG, Basel (AU)

FAPESP's process: 09/04240-0 - Effects of sleep deprivation and sleep restriction on the integrity of the skin: quantification of the skin collagen in hairless mice.
Grantee:Vanessa Kahan
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 07/01228-4 - Medium-term oral carcinogenesis assay induced by 4-nitroquinoline 1-oxide in rats: putative biomarkers involved into its pathogenesis
Grantee:Daniel Araki Ribeiro
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 11/14462-0 - EFFECTS OF CHRONIC MORPHINE ADMINISTRATION IN WOUND HEALING OF SLEEP DEPRIVED MICE
Grantee:Flávia de Mattos Egydio
Support Opportunities: Scholarships in Brazil - Master