| Full text | |
| Author(s): |
Costa-da-Silva, Andre Luis
[1, 2]
;
Kojin, Bianca B.
[3]
;
Marinotti, Osvaldo
[3]
;
James, Anthony A.
[3, 4]
;
Capurro, Margareth Lara
[1, 2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, Lab Mosquitos Geneticamente Modificados, BR-05508000 Sao Paulo - Brazil
[2] INCT EM, Rio De Janeiro - Brazil
[3] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92697 - USA
[4] Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92697 - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | PARASITES & VECTORS; v. 6, DEC 24 2013. |
| Web of Science Citations: | 15 |
| Abstract | |
Background: Aedes aegypti mosquitoes are the main vectors of dengue viruses. Despite global efforts to reduce the prevalence of dengue using integrated vector management strategies, innovative alternatives are necessary to help prevent virus transmission. Detailed characterizations of Ae. aegypti genes and their products provide information about the biology of mosquitoes and may serve as foundations for the design of new vector control methods. Findings: We studied the Ae. aegypti gene, AAEL010714, that encodes a two-domain odorant-binding protein, AaegOBP45. The predicted gene structure and sequence were validated, although single nucleotide polymorphisms were observed. Transcriptional and translational products accumulate in the ovaries of blood fed females and are not detected or are at low abundance in other tissues. Conclusions: We validated the Ae. aegypti AAEL010714 gene sequence and characterized the expression profile of a two-domain OBP expressed in ovaries. We propose that AaegOBP45 function as a component of the mosquito eggshell. (AU) | |