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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Grape juice concentrate protects reproductive parameters of male rats against cadmium-induced damage: a chronic assay

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Author(s):
Pires, Vanessa Cardoso [1] ; Boiago Golluecke, Andrea Pittelli [2, 3] ; Ribeiro, Daniel Araki [1] ; Lungato, Lisandro [4] ; D'Almeida, Vania [4] ; Aguiar, Jr., Odair [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP - Brazil
[2] Univ Catolica Santos, Hexalab, Santos, SP - Brazil
[3] Univ Catolica Santos, Dept Nutr, Santos, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BRITISH JOURNAL OF NUTRITION; v. 110, n. 11, p. 2020-2029, DEC 14 2013.
Web of Science Citations: 15
Abstract

The aim of the present study was to investigate the effects of long-term grape juice concentrate (GJC) consumption, in two dosages, on the reproductive parameters of cadmium-exposed male rats. The effects of the concentrate on body mass gain, plasma testosterone levels, reproductive organ weights, daily sperm production, sperm morphology, testis histopathological and histomorphometrical parameters, and testicular antioxidant markers were investigated. Wistar rats (n 54) were distributed into six groups: CdCl2; cadmium and grape juice I (1.18 g/kg per d); cadmium and grape juice II (2.36 g/kg per d); grape juice I (1.18 g/kg per d); grape juice II (2.36 g/kg per d); control. A single dose of CdCl2 (1.2 mg/kg body weight (BW)) was injected intraperitoneally and the grape juice was administered orally for 56 d. The results indicated that cadmium changed all reproductive and antioxidant parameters. At dosage I (1.18 g/kg BW), GJC consumption did not show the effects against cadmium-induced damages. In contrast, at dosage II (2.36 g/kg BW), the GJC improved the gonadosomatic index (P=0.003), serum testosterone levels (P=0.001), the relative weight of epididymis (P=0.013) and ventral prostate (P=0.052), the percentage of normal sperm (P=0.001), and histopathological and histomorphometrical parameters. In addition, at this dosage, normalisation of the enzymatic activity of superoxide dismutase (P=0.001) and of testicular levels of glutathione (P=0.03) were observed. The parameters of the non-exposed rats did not depict significant alterations. In conclusion, the product was able to act as a protector of reproductive function against cadmium-induced damage. Such a property was expressed in a dose-dependent manner as the more effective dose was dosage II. The GJC acted possibly by antioxidant mechanisms. (AU)

FAPESP's process: 11/22811-5 - Effects of the grape juice concentrate and the Brazilian nut extract (Bertholletia excelsa) on the cadmiun-induced damage in the spermatogenesis and other reproductive parameters of male rats
Grantee:Odair Aguiar Junior
Support Opportunities: Regular Research Grants
FAPESP's process: 11/03873-0 - Effects of concentrated grape juice, with high amount of resveratrol and other polyphenols, in reproductive parameters of rats exposed to cadmium chloride
Grantee:Vanessa Cardoso Pires
Support Opportunities: Scholarships in Brazil - Master