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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

HE4 can help discriminate women with malignant ovarian tumors only if CA125 levels are elevated

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Author(s):
Pitta, Denise da Rocha [1] ; Sarian, Luis Otavio [1] ; Campos, Elisabete Aparecida [1] ; De Angelo Andrade, Liliana Lucci [2] ; Sallum, Luis Felipe [1] ; Braganca, Joana Froes [1] ; Campos, Camila de Mello [1] ; Derchain, Sophie [1]
Total Authors: 8
Affiliation:
[1] State Univ Campinas UNICAMP, Fac Med Sci, Dept Obstet & Gynecol, BR-13083970 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Fac Med Sci, Dept Pathol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: International Journal of Biological Markers; v. 28, n. 4, p. E377-E386, OCT-DEC 2013.
Web of Science Citations: 1
Abstract

Objective: To evaluate the performance of mesothelin, CA125, HE4 and ROMA index in the detection of malignant ovarian tumors. Study Design: This is a cross-sectional study including 199 women with adnexal masses (67 with malignant tumors and 132 with benign tumors) and 150 healthy women (controls). We used a recursive multivariate partitioning algorithm to assess the contribution of each of the serum markers and the ROMA index to the discrimination of women with malignant tumors. Also, the areas under the ROC curves (AUC) for each of the serum markers and for the ROMA index were compared using the Venkatraman's projection-permutation test. Results: In the recursive model, CA125 had the best performance in discriminating women with malignant tumors. In women with normal-range CA125 levels, none of the other markers contributed to the discrimination of women with malignant tumors. In women with elevated CA125 levels, elevated HE4 levels were associated with an increased risk of harboring a malignant tumor. The AUC for mesothelin was smaller than that for all the other curves, and both the ROMA index and CA125 had better AUC than HE4. Conclusion: In women with normal CA125 levels, neither mesothelin nor HE4 contributed to discriminate women with malignant ovarian tumors; however, for women with elevated CA125 levels HE4 may help discriminating those who have a malignant ovarian tumor. (AU)

FAPESP's process: 12/15059-8 - Evaluation of biomarkers in the detection of malignant neoplasia in women with adnexal mass
Grantee:Sophie Françoise Mauricette Derchain
Support Opportunities: Regular Research Grants