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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Depression during gestation in adolescent mothers interferes with neonatal neurobehavior

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Author(s):
de Moraes Barros, Marina Carvalho [1] ; Mitsuhiro, Sandro Sendim [2, 3] ; Chalem, Elisa [4] ; Laranjeira, Ronaldo Ramos [2, 3, 5] ; Guinsburg, Ruth [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Pediat, Div Neonatal Med, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Natl Sci & Technol Inst Policies Alcohol & Drugs, Sao Paulo - Brazil
[3] Conselho Nacl Desenvolvimento Cient & Tecnol CNPq, Sao Paulo - Brazil
[4] UNIFESP EPM, Res Unit Alcohol & Other Drugs, Sao Paulo - Brazil
[5] UNIFESP EPM, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Revista Brasileira de Psiquiatria; v. 35, n. 4, p. 353-359, OCT-DEC 2013.
Web of Science Citations: 3
Abstract

Objective: To compare the neurobehavior of neonates born to adolescent mothers with and without depression during gestation. Methods: This prospective cross-sectional study included healthy term neonates born to adolescent mothers with untreated depression during gestation, without exposure to legal or illicit drugs, and compared them with infants born to adolescent mothers without psychiatric disorders. Maternal psychiatric diagnoses were assessed by the Composite International Diagnostic Interview (CIDI 2.1) and neonatal neurobehavior by the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) at 24 to 72 hours of life. Neurobehavioral outcomes were analyzed by ANOVA adjusted for confounders. Results: 37 infants born to mothers with depression during gestation were compared to 332 infants born to mothers without psychiatric disorders. Infants of mothers with depression had smaller head circumferences. Significant interactions of maternal depression and male gender, gestational age > 40 weeks, regional anesthesia during delivery, vaginal delivery, and infant head circumference ≥ 34 cm were found. Worse performance was noted in the following neonatal neurobehavioral parameters: arousal, excitability, lethargy, hypotonicity, and signs of stress and abstinence. Conclusion: Infants born to adolescent mothers with depression exhibit some behavioral changes in the first days of life. These changes are associated with infant sex, gestational age, type of anesthesia, mode of delivery, and head circumference. (AU)

FAPESP's process: 00/10293-5 - Drug abuse among pregnant adolescents
Grantee:Ronaldo Laranjeira
Support Opportunities: Research Projects - Thematic Grants