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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of 1alpha-HYD and 24-HYD in bovine kidney mediated by vitamin D-3 supplementation

Full text
Author(s):
Rezende, L. R. [1] ; Delgado, E. F. [1] ; Junior, A. R. L. [2] ; Gasparin, G. [1] ; Jorge, E. C. [3] ; Mourao, G. B. [1] ; Coutinho, L. L. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Dept Zootecnia, Escola Super Agr Luiz de Queiroz, Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Dept Ciencias Basicas, Fac Zootecnia & Engn Alimentos, Pirassununga, SP - Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Morfol, Belo Horizonte, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Genetics and Molecular Research; v. 12, n. 4, p. 6611-6618, 2013.
Web of Science Citations: 0
Abstract

In order to better understand vitamin D-3 in cattle metabolism, we quantified 1alpha-HYD and 24-HYD gene expression. In the kidneys of 35 male Nellore cattle, these were divided into a control group and two treatment groups (2 x 10(6) international units of vitamin D-3 administered for 2 or 8 consecutive days pre-slaughter). Vitamin D-3 supplementation resulted in a significant increase in 1alpha-HYD gene expression; however, significantly increased 24-HYD gene expression was only detected in cattle that had 8 days of supplementation. The finding of upregulation of 24-HYD due to vitamin D supplementation is in line with the expected rise in 24,25-di-hydroxy-vitamin D-3 synthesis observed when plasma vitamin D-3 concentrations are high, stimulating excretion by the organism. On the other hand, upregulation of 1alpha-HYD was unexpected, since vitamin D-3 supplementation has been reported to impact these two genes in opposite directions. We conclude that vitamin D-3 metabolism in these animals is more complex than previously reported. (AU)

FAPESP's process: 06/06963-1 - Interaction between vitamin D3 supplementation in the diet and solar exposure on qualitative characteristics of beef
Grantee:Eduardo Francisquine Delgado
Support Opportunities: Regular Research Grants
FAPESP's process: 08/01986-9 - Expression analysis of genes associated with the metabolism of vitamin D3 and their association with meat tenderness in Nelore breed.
Grantee:Lilian Ribeiro Rezende
Support Opportunities: Scholarships in Brazil - Master