Chemical modification of high density lipoprotein subfractions - HDL2 and HDL3 - after use of atorvastatin

Author(s)

de Souza Zago, Vanessa Helena ^{[1, 2]} ; Tanus-Santos, Jose Eduardo ^[3] ; Gardin Danelon, Mirian Regina ^{[1, 2]} ; Parra, Eliane Soler ^{[1, 2]} ; Alexandre, Fernanda ^{[1, 2]} ; Vieira, Isabela Calanca ^{[1, 2]} ; Panzoldo, Natalia Baratella ^{[1, 2]} ; D'Alexandri, Fabio Luis ^{[1, 2]} ; Rocha Quintao, Eder Carlos ^[4] ; de Faria, Eliana Cotta ^{[1, 2]}

Affiliation

^[1] Univ Estadual Campinas, Fac Med Sci, Lipid Lab, Dept Clin Pathol, BR-13084971 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Fac Med Sci, Ctr Med & Expt Surg, BR-13084971 Campinas, SP - Brazil

^[3] Univ Sao Paulo, Fac Med Sci, Dept Pharmacol, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Fac Med Sci, Lipids Lab, Sao Paulo - Brazil

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS; v. 52, n. 4, p. 277-283, APR 2014.
• Web of Science Citations: 2

Abstract

Regardless of its effect on the concentrations of serum cholesterol, statins exert pleiotropic effects, including the regulation of endothelial function, reduced oxidative stress and inflammation, as well as a slight improvement in the concentrations of high density lipoprotein (HDL). However, its role on the composition of HDL is not yet established. The aim of this study was to evaluate the composition of HDL subfractions, HDL2 and HDL3, after 14 days of placebo and atorvastatin (10 mg/day) use in 30 asymptomatic volunteers. The serum parameters and the HDL subfractions compositions were determined using radiometric, nephelometric and biochemical enzymatic methods. We observed significant reductions of total cholesterol, low density lipoprotein (LDL) and apolipoprotein B-100 by 28%, 40% and 38%, respectively. The analyses of chemical composition of the subfractions revealed a lower lipid protein ratio in HDL2, suggesting enrichment in proteins, and also lower in HDL3, probably by an increase in the number of particles. Several mechanisms can be suggested for the effects observed after the use of atorvastatin, such as a possible action on the reverse cholesterol transport (decreased activity of hepatic lipase and increased phospholipid transfer protein, PLTP), which would explain the enrichment of HDL. The results suggest that statin use may be relevant in the primary prevention of atherosclerosis not only by its lowering effect on LDL-cholesterol and its anti-inflammatory effect but also by beneficial changes in HDL subfractions. (AU)

• FAPESP's process: 06/60585-9 - Relation of the plasma HDL-cholesterol concentration with blood monocyte and whole body cholesterol metabolism parameters
• Grantee: Eder Carlos Rocha Quintão
• Support Opportunities: Research Projects - Thematic Grants