Evaluation of the anti-helminthic activity of crude extracts from the Brazilian Amazon and Mata Atlântica plants against Haemonchus contortus

Author(s)

M.P.V. Cunha ^[1] ; A.F. Alves Neto ^[2] ; I.B. Suffredini ^[3] ; L.J.C. Abel ^[4]

Affiliation

^[1] Universidade Paulista

^[2] Universidade Paulista

^[3] Universidade Paulista

^[4] Universidade Paulista

• Document type: Journal article
• Source: Arquivo Brasileiro de Medicina Veterinária e Zootecnia; v. 66, n. 2, p. 374-380, 2014-04-00.

Abstract

Helminthosis play a crucial role in small ruminant production leading to enormous economic losses particularly in areas where extensive grazing is practiced. It causes a loss of production through mortality, weight loss, reduced milk and wool production. Haemonchus contortus is a highly pathogenic small ruminant helminthes parasite, which is capable of causing acute diseases and high mortality. Therefore, there is an urgent need to seek alternative or complementary solutions to the control of parasitic nematodes of ruminants. The tropical forests concentrate the highest biodiversity in the world, particularly those located in Brazil, whose species richness is estimated to account for 20% of the total world richness and little is known about the chemical and pharmacological potentialities of Brazilian tropical forests. In this work, organic and aqueous extracts were tested on eggs and in the larval development test on Haemonchus contortus. The organic extract obtained from leaves and fruits of Trichilia sp. and the aqueous extract obtained from the aerial organs of Phyllanthus attenuates showed significant activity related to the inhibition of H. contortus egg eclosion. In vitro results suggest that both extracts, as well as eleven other active extracts, can offer alternatives in sheep worm control. (AU)