Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of surgical margins in oral cancer using in situ fluorescence spectroscopy

Full text
Author(s):
Noronha Francisco, Ana Lucia [1] ; Correr, Wagner Rafael [2] ; Lopes Pinto, Clovis Antonio [3] ; Goncalves Filho, Joao [4, 5] ; Chulam, Thiago Celestino [4, 5] ; Kurachi, Cristina ; Kowalski, Luiz Paulo [4, 5]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Sao Carlos Inst Phys, Dept Phys & Mat Sci, BR-13566590 Sao Carlos, SP - Brazil
[3] AC Camargo Canc Ctr, Dept Pathol, BR-01509900 Sao Paulo - Brazil
[4] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo - Brazil
[5] Natl Inst Sci & Technol Oncogenom INCITO, BR-01509900 Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Oral Oncology; v. 50, n. 6, p. 593-599, JUN 2014.
Web of Science Citations: 12
Abstract

Oral cancer is a public health problem with high prevalence in the population. Local tumor control is best achieved by complete surgical resection with adequate margins. A disease-free surgical margin correlates with a lower rate of local recurrence and a higher rate of disease-free survival. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection. The technique, which evaluates the biochemical composition and structure of tissue fluorescence, is relatively simple, fast and, accurate. Objectives: This study aimed to compare oral squamous cell carcinoma lesions to surgical margins and the mucosa of healthy volunteers by fluorescence spectroscopy. Materials and methods: The sample consisted of 56 individuals, 28 with oral squamous cell carcinoma and 28 healthy volunteers with normal oral mucosa. Thirty six cases (64.3%) were male and the mean age was 60.9 years old. The spectra were classified and compared to histopathology to determine fluorescence efficiency for diagnostic discrimination of tumors. Results: In the analysis of the other cases we observed discrimination between normal mucosa, injury and margins. At two-year follow up, three individuals had local recurrence, and in two cases investigation fluorescence in the corresponding area showed qualitative differences in spectra between the recurrence area and the area without recurrence at the same anatomical site in the same patient. Conclusion: In situ analysis of oral mucosa showed the potential of fluorescence spectroscopy as a diagnostic tool that can aid in discrimination of altered mucosa and normal mucosa. (c) 2014 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/10802-1 - Fluorescence imaging systems for detection of premalignant lesions and squamous cell carcinoma of the oral cavity
Grantee:Luiz Paulo Kowalski
Support Opportunities: Regular Research Grants
FAPESP's process: 98/14270-8 - Center for Optical and Photonics Science
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC