Phytate decreases oxidative damage caused by labile forms of iron in solution, blood plasma and in HeLa cells

Author(s)

Schleh, Frederico A. ^[1] ; Chiarelli-Neto, Orlando ^[1] ; Fontes, Mayara N. ^[1] ; Najjar, Renato ^[1] ; Esposito, Breno P. ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 25, n. 6, p. 1036-1040, JUN 2014.
• Web of Science Citations: 1

Abstract

Phytate (PHYT, myo-inositol 1,2,3,4,5,6-hexakisphosphate) is a natural product with strong effect on the bioavailability of minerals, especially iron. In this work, we investigated the antioxidant effects of PHYT on models of iron overload disorders (labile plasma iron and labile iron pool) both in solution and in HeLa cells. PHYT has a considerable antioxidant effect, with the benefit of being cell permeant and a normal constituent of human diet. Our results suggest that PHYT may assist organism defenses against iron-overload stress. (AU)

• FAPESP's process: 11/50318-1 - Development of compounds with pharmacological or medicinal interest and of systems for their transport, detection and recognition in biological media
• Grantee: Ana Maria da Costa Ferreira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 12/04875-9 - Chelators for the depletion of plasma or cell reservoirs of labile iron
• Grantee: Frederico Andreotti Schleh
• Support Opportunities: Scholarships in Brazil - Scientific Initiation