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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Integrated Proteomics Identified Up-Regulated Focal Adhesion-Mediated Proteins in Human Squamous Cell Carcinoma in an Orthotopic Murine Model

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Author(s):
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Granato, Daniela C. [1] ; Zanetti, Mariana R. [1] ; Kawahara, Rebeca [1] ; Yokoo, Sami [1] ; Domingues, Romenia R. [1] ; Aragao, Annelize Z. [1] ; Agostini, Michelle [2, 3] ; Carazzolle, Marcelo F. [1] ; Vidal, Ramon O. [1] ; Flores, Isadora L. [1, 2] ; Korvala, Johanna [4] ; Cervigne, Nilva K. [2] ; Silva, Alan R. S. [2] ; Coletta, Ricardo D. [2] ; Graner, Edgard [2] ; Sherman, Nicholas E. [5] ; Paes Leme, Adriana F. [1]
Total Authors: 17
Affiliation:
[1] CNPEM, LNBio, Lab Espectrometria Massas, Lab Nacl Biociencias, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Odontol Piracicaba, Piracicaba - Brazil
[3] Univ Fed Rio de Janeiro, Fac Odontol, Rio De Janeiro - Brazil
[4] Univ Oulu, Inst Dent, Oulu - Finland
[5] Univ Virginia, WM Keck Biomed Mass Spectrometry Lab, Charlottesville, VA - USA
Total Affiliations: 5
Document type: Journal article
Source: PLoS One; v. 9, n. 5 MAY 23 2014.
Web of Science Citations: 5
Abstract

Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules. (AU)

FAPESP's process: 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner
Grantee:Oslei Paes de Almeida
Support type: Multi-user Equipment Program
FAPESP's process: 10/19278-0 - Study of regulation of ADAMs in oral cancer
Grantee:Adriana Franco Paes Leme
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/02267-9 - Identifying ADAM17 partners and mapping the domains responsible for its interaction with other proteins.
Grantee:Daniela Campos Granato
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 11/22421-2 - Determination of cleavage sites of recombinant ADAM-17 in human cells
Grantee:Rebeca Kawahara Sakuma
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 09/54067-3 - Acquisition of a mass spectrometer coupled to a liquid chromatography system for increasing the capacity to meet the needs of users and for making new technologies available in the Laboratory of Mass Spectrometry
Grantee:Adriana Franco Paes Leme
Support type: Multi-user Equipment Program