Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Platelet-Rich Plasma, Low-Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study

Full text
Author(s):
Show less -
Nagata, Maria J. H. [1] ; de Campos, Natalia [1] ; Messora, Michel R. [2] ; Pola, Natalia M. [1] ; Santinoni, Carolina S. [1] ; Bomfim, Suely R. M. [3] ; Fucini, Stephen E. [1] ; Ervolino, Edilson [4] ; de Almeida, Juliano M. [1] ; Theodoro, Leticia H. [1] ; Garcia, Valdir G. [1]
Total Authors: 11
Affiliation:
[1] Sao Paulo State Univ, UNESP, Dent Sch Aracatuba, Dept Surg & Integrated Clin, Aracatuba, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Sch Dent, Dept Oral & Maxillofacial Surg & Traumatol, USP, Ribeirao Preto, SP - Brazil
[3] Sao Paulo State Univ, Vet Sch Aracatuba, Dept Clin Surg & Anim Reprod, Sao Paulo - Brazil
[4] Sao Paulo State Univ, UNESP, Dept Basic Sci, Dent Sch Aracatuba, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Periodontology; v. 85, n. 6, p. 770-778, JUN 2014.
Web of Science Citations: 8
Abstract

Background: This study histomorphometrically analyzes the influence of platelet- rich plasma (PRP), low- level laser therapy (LLLT), or their combination on the healing of periodontal fenestration defects (PFDs) in rats. Methods: PFDs were surgically created in the mandibles of 80 rats. The animals were randomly divided into four groups: 1) C (control) and 2) PRP, defects were filled with blood clot or PRP, respectively; 3) LLLT and 4) PRP/LLLT, defects received laser irradiation, were filled with blood clot or PRP, respectively, and then irradiated again. Animals were euthanized at either 10 or 30 days post-surgery. Percentage of new bone (NB), density of newly formed bone (DNB), new cementum (NC), and extension of remaining defect (ERD) were histomorphometrically evaluated. Data were statistically analyzed (analysis of variance; Tukey test, P < 0.05). Results: At 10 days, group PRP presented ERD significantly lower than group C. At 30 days, group PRP presented NB and DNB significantly greater than group C. Groups LLLT, PRP, and PRP/LLLT showed significant NC formation at 30 days, with collagen fibers inserted obliquely or perpendicularly to the root surface. NC formation was not observed in any group C specimen. Conclusions: LLLT, PRP, or their combination all promoted NC formation with a functional periodontal ligament. The combination PRP/LLLT did not show additional positive effects compared to the use of either therapy alone. (AU)