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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Identification of glycosylated regions in pneumococcal PspA conjugated to serotype 6B capsular polysaccharide

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Author(s):
Barazzone, Giovana Cappio [1] ; Pinto, Vittoria [2] ; Donnarumma, Danilo [2] ; Tanizaki, Martha Massako [1] ; Norais, Nathalie [2] ; Berti, Francesco [2]
Total Authors: 6
Affiliation:
[1] Inst Butantan, Ctr Biotecnol, BR-05503900 Sao Paulo - Brazil
[2] Novartis Vaccines & Diagnost, Siena - Italy
Total Affiliations: 2
Document type: Journal article
Source: GLYCOCONJUGATE JOURNAL; v. 31, n. 3, p. 259-269, APR 2014.
Web of Science Citations: 2
Abstract

Conjugate vaccines are being widely used since their introduction. Nowadays the interest in these vaccines is still growing and new antigens and conjugate chemistry are being studied and developed. Pneumococcal surface protein A (PspA) is one of the most studied pneumococcal antigens and is an important vaccine candidate. One approach to broaden the conjugate vaccine coverage could be the conjugation of the polysaccharide to a pneumococcal protein such as PspA. Previous results have shown that conjugated recombinant fragment of PspA (rPspA) not only maintained but also in some conjugates improved the induction of protective antibodies raised against the protein carrier. We describe here a characterization study to identify the domains of Streptococcus pneumoniae recombinant PspA (rPspA), from family 1 clade 1 and family 2 clade 3, involved in the conjugation with serotype 6B capsular polysaccharide. (AU)

FAPESP's process: 08/05207-4 - Pneumococcal conjugate vaccine: capsular polysaccharide - pneumococcal surface protein A
Grantee:Martha Massako Tanizaki
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/13015-3 - Identification of glycosylation sites of S. pneumoniae capsular polysaccharide-PspA conjugates by mass spectrometry
Grantee:Giovana Cappio Barazzone
Support type: Scholarships abroad - Research