| Full text | |
| Author(s): |
José Eduardo Peixoto-Santos
[1]
;
Orfa Yineth Galvis-Alonso
[2]
;
Tonicarlo R. Velasco
[3]
;
Ludmyla Kandratavicius
[4]
;
João Alberto Assirati Jr
[5]
;
Carlos Gilberto Carlotti
[6]
;
Renata Caldo Scandiuzzi
[7]
;
Luciano Neder Serafini
[8]
;
João Pereira Leite
[9]
Total Authors: 9
|
| Affiliation: | [1] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neuroscience and Behavior
[2] São José do Rio Preto Medical School. Department of Molecular Biology
[3] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neuroscience and Behavior
[4] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neuroscience and Behavior
[5] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neurosurgery
[6] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neurosurgery
[7] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neuroscience and Behavior
[8] University of São Paulo. Ribeirão Preto School of Medicine. Department of Pathology
[9] University of São Paulo. Ribeirão Preto School of Medicine. Department of Neuroscience and Behavior
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | Journal of Epilepsy and Clinical Neurophysiology; v. 18, n. 1, p. 16-20, 2012-03-00. |
| Abstract | |
In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns. (AU) | |
| FAPESP's process: | 05/56447-7 - Research through images from high field magnetic resonance aimed at studies in humans |
| Grantee: | João Pereira Leite |
| Support Opportunities: | Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants |
| FAPESP's process: | 09/53447-7 - Synaptic and non synaptic mechanisms of refractory epilepsy and its implications in searching for new therapeutic strategies: translational approach |
| Grantee: | João Pereira Leite |
| Support Opportunities: | Research Projects - Thematic Grants |