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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Different levels of MT-I/II between patients with MTLE with or without seizure generalization: does hippocampal MT-I/II affects seizure spread, or does seizure spread promotes differential expression of MT-I/II?

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José Eduardo Peixoto-Santos ; Orfa Yineth Galvis-Alonso ; Tonicarlo R. Velasco ; Ludmyla Kandratavicius ; João Alberto Assirati Jr ; Carlos Gilberto Carlotti ; Renata Caldo Scandiuzzi ; Luciano Neder Serafini ; João Pereira Leite
Total Authors: 9
Document type: Journal article
Source: Journal of Epilepsy and Clinical Neurophysiology; v. 18, n. 1, p. 16-20, Mar. 2012.

In the central nervous system, zinc is released along with glutamate during neurotransmission and, in excess, can promote neuronal death. Experimental studies have shown that metallothioneins I/II (MT-I/II), which chelate free zinc, can affect seizures and reduce neuronal death after status epilepticus. Our aim was to evaluate the expression of MT-I/II in the hippocampus of patients with temporal lobe epilepsy (TLE). Hippocampi from patients with pharmacoresistant mesial temporal lobe epilepsy (MTLE) were evaluated for expression of MT-I/II and for neuronal, astroglial, and microglial populations. Compared to control cases, MTLE group displayed widespread increase in MT-I/II expression, astrogliosis and reduced neuronal population. MT-I/II levels did not correlate with any clinical variables, but patients with secondary generalized seizures (SGS) had less MT-I/II than patients without SGS. In conclusion, MT-I/II expression was increased in hippocampi from MTLE patients and our data suggest that it may be associated with different seizure spread patterns. (AU)

FAPESP's process: 09/53447-7 - Synaptic and non synaptic mechanisms of refractory epilepsy and its implications in searching for new therapeutic strategies: translational approach
Grantee:João Pereira Leite
Support type: Research Projects - Thematic Grants
FAPESP's process: 05/56447-7 - Research through images from high field magnetic resonance aimed at studies in humans
Grantee:João Pereira Leite
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants