Effects of diet and exercise training on neurovascular control during mental stress in obese women

Author(s):Show less -

A.C. Tonacio ^[1] ; I.C. Trombetta ^[2] ; M.U.P.B. Rondon ^[3] ; L.T. Batalha ^[4] ; F.H.S. Kuniyoshi ^[5] ; M.C. Laterza ^[6] ; P.H. Suzuki ; M.M.G. Gowdak ^[8] ; A.C.P. Barretto ^[9] ; A. Halpern ^[10] ; S.M.F. Villares ^[11] ; C.E. Negrão

Affiliation:Show less -

^[1] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[2] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[3] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[4] Universidade de São Paulo. Faculdade de Medicina. Disciplina de Endocrinologia

^[5] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[6] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[8] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[9] Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas

^[10] Universidade de São Paulo. Faculdade de Medicina. Disciplina de Endocrinologia

^[11] Universidade de São Paulo. Faculdade de Medicina. Disciplina de Endocrinologia

• Document type: Journal article
• Source: Brazilian Journal of Medical and Biological Research; v. 39, n. 1, p. 53-62, 2006-01-00.

Abstract

Since neurovascular control is altered in obese subjects, we hypothesized that weight loss by diet (D) or diet plus exercise training (D + ET) would improve neurovascular control during mental stress in obese women. In a study with a dietary reduction of 600 kcal/day with or without exercise training for 4 months, 53 obese women were subdivided in D (N = 22, 33 ± 1 years, BMI 34 ± 1 kg/m²), D + ET (N = 22, 33 ± 1 years, BMI 33 ± 1 kg/m²), and nonadherent (NA, N = 9, 35 ± 2 years, BMI 33 ± 1 kg/m²) groups. Muscle sympathetic nerve activity (MSNA) was measured by microneurography and forearm blood flow by venous occlusion plethysmography. Mental stress was elicited by a 3-min Stroop color word test. Weight loss was similar between D and D + ET groups (87 ± 2 vs 79 ± 2 and 85 ± 2 vs 76 ± 2 kg, respectively, P < 0.05) with a significant reduction in MSNA during mental stress (58 ± 2 vs 50 ± 2, P = 0.0001, and 59 ± 3 vs 50 ± 2 bursts/100 beats, P = 0.0001, respectively), although the magnitude of the response was unchanged. Forearm vascular conductance during mental stress was significantly increased only in D + ET (2.74 ± 0.22 vs 3.52 ± 0.19 units, P = 0.02). Weight loss reduces MSNA during mental stress in obese women. The increase in forearm vascular conductance after weight loss provides convincing evidence for D + ET interventions as a nonpharmacologic therapy of human obesity. (AU)

• FAPESP's process: 98/15983-8 - Genetic and ambiental aspects of obesity
• Grantee: Carlos Eduardo Negrão
• Support Opportunities: Research Projects - Thematic Grants