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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functional and morphological effects of resistance exercise on disuse-induced skeletal muscle atrophy

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Author(s):
Nicastro, H. [1] ; Zanchi, N. E. [2] ; da Luz, C. R. [1] ; Lancha, Jr., A. H. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Lab Nutr & Metab Aplicados Atividade Motora, Escola Educ Fis & Esporte, BR-09500900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: Brazilian Journal of Medical and Biological Research; v. 44, n. 11, p. 1070-1079, NOV 2011.
Web of Science Citations: 3
Abstract

The reduction of skeletal muscle loss in pathological states, such as muscle disuse, has considerable effects in terms of rehabilitation and quality of life. Since there is no currently effective and safe treatment available for skeletal muscle atrophy, the search for new alternatives is necessary. Resistance exercise (RE) seems to be an important tool in the treatment of disuse-induced skeletal muscle atrophy by promoting positive functional (strength and power) and structural (hypertrophy and phenotypic changes) adaptive responses. Human and animal studies using different types of resistance exercise (flywheel, vascular occlusion, dynamic, isometric, and eccentric) have obtained results of great importance. However, since RE is a complex phenomenon, lack of strict control of its variables (volume, frequency, intensity, muscle action, rest intervals) limits the interpretation of the impact of the manipulation on skeletal muscle remodeling and function under disuse. The aim of this review is to critically describe the functional and morphological role of resistance exercise in disuse-induced skeletal muscle atrophy with emphasis on the principles of training. (AU)

FAPESP's process: 10/07062-3 - Leucine and skeletal muscle disuse: clinical anti-atrophic efficacy and related mechanisms
Grantee:Humberto Nicastro Silva
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 11/04690-6 - Effects of leucine and branched-chaim amino acids supplementation on resistance exercise-induced muscle damage and inflammation: a randomized, double-blind, and placebo-controlled study
Grantee:Claudia Ribeiro da Luz
Support Opportunities: Scholarships in Brazil - Master