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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring

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Author(s):
Maiellaro, Marilia [1] ; Correa-Costa, Matheus [2] ; Vitoretti, Luana Beatriz [3] ; Gimenes Junior, Joao Antonio [3] ; Saraiva Camara, Niels Olsen [2] ; Tavares-de-Lima, Wothan [3] ; Poliselli Farsky, Sandra Helena [1] ; Lino-dos-Santos-Franco, Adriana [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, BR-05508900 Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Toxicology and Applied Pharmacology; v. 278, n. 3, p. 266-274, AUG 1 2014.
Web of Science Citations: 18
Abstract

Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown. Nevertheless, no data are available regarding the programming mechanisms after FA exposure and its repercussions for the immune systems of offspring. In this study, our objective was to investigate the effects of low-dose exposure of FA on pregnant rats and its repercussion for the development of allergic lung inflammation in offspring. Pregnant Wistar rats were assigned in 3 groups: P (rats exposed to FA (0.75 ppm, 1 h/day, 5 days/week, for 21 days)), C (rats exposed to vehicle of FA (distillated water)) and B (rats non-manipulated). After 30 days of age, the offspring was sensitised with ovalbumin (OVA)-alum and challenged with aerosolized OVA (1%, 15 min, 3 days). After 24 h the OVA challenge the parameters were evaluated. Our data showed that low-dose exposure to FA during pregnancy induced low birth weight and suppressed the development of allergic lung inflammation and tracheal hyperresponsiveness in offspring by mechanisms mediated by reduced anaphylactic antibodies synthesis, IL-6 and TNF-alpha secretion. Elevated levels of IL-10 were found. Any systemic alteration was detected in the exposed pregnant rats, although oxidative stress in the uterine environment was evident at the moment of the delivery based on elevated COX-1 expression and reduced cNOS and SOD-2 in the uterus. Therefore, we show the putative programming mechanisms induced by FA on the immune system for the first time and the mechanisms involved may be related to oxidative stress in the foetal microenvironment. (C) 2014 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/51711-9 - Exposure to ambient and occupational pollution in uterus and its repercussion on development of allergic lung inflammation in offspring: correlation with epigenetic mechanisms
Grantee:Adriana Lino dos Santos Franco
Support type: Research Grants - Young Investigators Grants