Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fluorescence spectroscopy for the detection of potentially malignant disorders and squamous cell carcinoma of the oral cavity

Full text
Author(s):
Noronha Francisco, Ana Lucia [1] ; Correr, Wagner Rafael [2] ; Azevedo, Luciane Hiramatsu [3] ; Kern, Vivian Galletta [3] ; Lopes Pinto, Clovis Antonio [4] ; Kowalski, Luiz Paulo [5, 6] ; Kurachi, Cristina [2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Sch Dent Piracicaba, Dept Oral Diag, BR-13414018 Piracicaba, SP - Brazil
[2] Univ Sao Paulo, Phys Inst Sao Carlos, Dept Phys & Mat Sci, BR-13566590 Sao Carlos, SP - Brazil
[3] Univ Sao Paulo, Sch Dent Sao Paulo, Special Lab Laser Dent, BR-05508000 Sao Paulo - Brazil
[4] AC Camargo Canc Ctr, Dept Pathol, BR-01509900 Sao Paulo - Brazil
[5] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, BR-01509900 Sao Paulo - Brazil
[6] INCITO, Natl Inst Sci & Technol Oncogenom, BR-01509900 Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Photodiagnosis and Photodynamic Therapy; v. 11, n. 2, p. 82-90, JUN 2014.
Web of Science Citations: 7
Abstract

Oral cancer is a public health problem with relevant incidence in the world population. The affected patient usually presents advanced stage disease and the consequence of this delay is a reduction in survival rates. Given this, it is essential to detect oral cancer at early stages. Fluorescence spectroscopy is a non-invasive diagnostic tool that can improve cancer detection in real time. It is a fast and accurate technique, relatively simple, which evaluates the biochemical composition and structure using the tissue fluorescence spectrum as interrogation data. Several studies have positive data regarding the tools for differentiating between normal mucosa and cancer, but the difference between cancer and potentially malignant disorders is not clear. The aim of this study was to evaluate the efficacy of fluorescence spectroscopy in the discrimination of normal oral mucosa, oral cancer, and potentially malignant disorders. The fluorescence spectroscopy was evaluated in 115 individuals, of whom 55 patients presented oral squamous cell carcinoma, 30 volunteers showing normal oral mucosa, and 30 patients having potentially malignant disorders. The spectra were classified and compared to histopathology to evaluate the efficiency in diagnostic discrimination employing fluorescence. In order to classify the spectra, a decision tree algorithm (C4.5) was applied. Despite of the high variance observed in spectral data, the specificity and sensitivity obtained were 93.8% and 88.5%, respectively at 406 nm excitation. These results point to the potential use of fluorescence spectroscopy as an important tool for oral cancer diagnosis and potentially malignant disorders. (C) 2014 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 08/57887-9 - National Institute of Oncogenomics
Grantee:Luiz Paulo Kowalski
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 98/14270-8 - Center for Optical and Photonics Science
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 09/12938-8 - Fluorescence spectroscopy for the detection of malignant oral lesions
Grantee:Ana Lucia Noronha Francisco
Support Opportunities: Scholarships in Brazil - Master