| Full text | |
| Author(s): |
Soeiro-de-Souza, Marcio Gerhardt
[1]
;
Bio, Danielle Soares
[2]
;
David, Denise Petresco
[3]
;
dos Santos, Jr., Domingos Rodrigues
;
Kerr, Daniel Shikanai
[5]
;
Gattaz, Wagner Farid
[6]
;
Machado-Vieira, Rodrigo
[7]
;
Moreno, Ricardo Albeto
[8]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo. IPq HC
[2] Univ Sao Paulo. IPq HC
[3] Univ Sao Paulo. IPq HC
[5] Univ Sao Paulo. HC
[6] Univ Sao Paulo. HC
[7] Univ Sao Paulo. HC
[8] Univ Sao Paulo. IPq HC
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | Journal of Affective Disorders; v. 136, n. 3, p. 370-376, FEB 2012. |
| Web of Science Citations: | 17 |
| Abstract | |
Background: One of the many cognitive deficits reported in bipolar disorder (BD) patients is facial emotion recognition (FER), which has recently been associated with dopaminergic catabolism. Catechol-O-methyltransferase (COMT) is one of the main enzymes involved in the metabolic degradation of dopamine (DA) in the prefrontal cortex (PFC). The COMT gene polymorphism rs4680 (Val(158)Met) Met allele is associated with decreased activity of this enzyme in healthy controls. The objective of this study was to evaluate the influence of Val(158)Met on FER during manic and depressive episodes in BD patients and in healthy controls. Materials and methods: 64 BD type I patients (39 in manic and 25 in depressive episodes) and 75 healthy controls were genotyped for COMT rs4680 and assessed for FER using the Ekman 60 Faces (EK60) and Emotion Hexagon (Hx) tests. Results: Bipolar manic patients carrying the Met allele recognized fewer surprised faces, while depressed patients with the Met allele recognized fewer ``angry{''} and ``happy{''} faces. Healthy homozygous subjects with the Met allele had higher FER scores on the Hx total score, as well as on ``disgust{''} and ``angry{''} faces than other genotypes. Conclusion: This is the first study suggesting that COMT rs4680 modulates FER differently during BD episodes and in healthy controls. This provides evidence that PFC DA is part of the neurobiological mechanisms of social cognition. Further studies on other COMT polymorphisms that include euthymic BD patients are warranted. ClinicalTrials.gov Identifier: NCT00969. (C) 2011 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 10/06230-0 - Genetic association study between single nucleotide polymorphisms and cognitive performance in young bipolar I patients: Licavalgene |
| Grantee: | Ricardo Alberto Moreno |
| Support Opportunities: | Regular Research Grants |