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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interaction between mesenchymal stem cells and Ti-30Ta alloy after surface treatment

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Capellato, Patricia [1] ; Escada, Ana L. A. [2] ; Popat, Ketul C. [3] ; Alves Claro, Ana P. R. [4]
Total Authors: 4
[1] Sao Paulo State Univ UNESP. Fac Engn Guaratingueta
[2] Sao Paulo State Univ UNESP. Fac Engn Guaratingueta
[3] Colorado State Univ. Dept Mech Engn
[4] Sao Paulo State Univ UNESP. Fac Engn Guaratingueta
Total Affiliations: 4
Document type: Journal article
Source: Journal of Biomedical Materials Research Part A; v. 102, n. 7, p. 2147-2156, JUL 2014.
Web of Science Citations: 0

In this study, in vitro cytocompatibility was investigated in the Ti-30Ta alloy after two kinds of surfaces treatments: alkaline and biomimetic treatment. Each condition was evaluated by scanning electron microscopy/energy-dispersive X-ray spectroscopy. Cellular adhesion, viability, protein expression, morphology, and differentiation were evaluated with Bone marrow stromal cells (MSCs) to investigate the short and long-term cellular response by fluorescence microscope imaging and colorimetric assays techniques. Two treatments exhibited similar results with respect to total protein content and enzyme activity as compared with alloy without treatment. However, it was observed improved of the biomineralization, bone matrix formation, enzyme activity, and MSCs functionality after biomimetic treatment. These results indicate that the biomimetic surface treatment has a high potential for enhanced osseointegration. (C) 2013 Wiley Periodicals, Inc. (AU)

FAPESP's process: 10/07231-0 - Study in vitro and in vivo of dental implants of Ti-30Ta experimental alloy after biomimetic surface treatment
Grantee:Ana Paula Rosifini Alves Claro
Support type: Regular Research Grants