Structural brain abnormalities are related to retinal nerve fiber layer thinning and disease duration in neuromyelitis optica spectrum disorders

Author(s):Show less -

von Glehn, Felipe ^{[1, 2]} ; Jarius, Sven ^[3] ; Cavalcanti Lira, Rodrigo Pessoa ^[4] ; Alves Ferreira, Maria Carolina ^[4] ; Ribeiro von Glehn, Fadua H. ^[2] ; Costa e Castro, Stella Maris ^[4] ; Beltramini, Guilherme Coco ^{[5, 2]} ; Bergo, Felipe P. G. ^[2] ; Farias, Alessandro S. ^[1] ; Brandao, Carlos Otavio ^{[1, 2]} ; Wildemann, Brigitte ^[3] ; Damasceno, Benito P. ^[2] ; Cendes, Fernando ^[2] ; Santos, Leonilda M. B. ^[1] ; Yasuda, Clarissa Lin ^[2]

Affiliation

^[1] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Neuroimmunol Unit, Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Neurol, Lab Neuroimaging, Campinas, SP - Brazil

^[3] Heidelberg Univ, Dept Neurol, Div Mol Neuroimmunol, D-69115 Heidelberg - Germany

^[4] Univ Estadual Campinas, Dept Ophthalmol, Campinas, SP - Brazil

^[5] Univ Estadual Campinas, Inst Phys Gleb Wataghin, Campinas, SP - Brazil

• Document type: Journal article
• Source: MULTIPLE SCLEROSIS; v. 20, n. 9, p. 1189-1197, AUG 2014.
• Web of Science Citations: 27

Abstract

Background: Although aquaporin-4 (AQP4) is widely expressed in the human brain cortex, lesions are rare in neuromyelitis optica (NMO) spectrum disorders (NMOSD). Recently, however, several studies have demonstrated occult structural brain atrophy in NMO. Objective: This study aims to investigate magnetic resonance imaging (MRI) patterns of gray matter (GM) and white matter (WM) abnormalities in patients with NMOSD and to assess the visual pathway integrity during disease duration correlation of the retinal nerve fiber layer (RNFL) and pericalcarine cortex thickness. Methods: Twenty-one patients with NMOSD and 34 matched healthy controls underwent both high-field MRI (3T) high-resolution T1-weighted and diffusion-tensor MRI. Voxel-based morphometry, cortical analyses (Freesurfer) and diffusion-tensor imaging (DTI) analyses (TBSS-FSL) were used to investigate brain abnormalities. In addition, RNFL measurement by optic-coherence tomography (OCT) was performed. Results: We demonstrate that NMOSD is associated with GM and WM atrophy, encompassing more frequently the motor, sensory and visual pathways, and that the extent of GM atrophy correlates with disease duration. Furthermore, we demonstrate for the first time a correlation between RNFL and pericalcarine cortical thickness, with cortical atrophy evolving over the course of disease. Conclusions: Our findings indicate a role for retrograde and anterograde neurodegeneration in GM atrophy in NMOSD. However, the presence atrophy encompassing almost all lobes suggests that additional pathomechanisms might also be involved. (AU)

• FAPESP's process: 12/04565-0 - Immunoregulatory function of HLA-G molecules in multiple sclerosis and experimental autoimmune encephalomyelitis
• Grantee: Leonilda Maria Barbosa dos Santos
• Support Opportunities: Regular Research Grants
• FAPESP's process: 11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases
• Grantee: Alessandro dos Santos Farias
• Support Opportunities: Research Grants - Young Investigators Grants