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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Spontaneous hypothermia in human sepsis is a transient, self-limiting, and nonterminal response

Texto completo
Autor(es):
Fonseca, Monique T. [1] ; Rodrigues, Abner C. [2] ; Cezar, Luana C. [1] ; Fujita, Andre [2] ; Soriano, Francisco G. [3] ; Steiner, Alexandre A. [1]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: Journal of Applied Physiology; v. 120, n. 12, p. 1394-1401, JUN 15 2016.
Citações Web of Science: 11
Resumo

Hypothermia in sepsis is generally perceived as something dysregulated and progressive although there has been no assessment on the natural course of this phenomenon in humans. This was the first study on the dynamics of hypothermia in septic patients not subjected to active rewarming, and the results were surprising. A sample of 50 subjects presenting with spontaneous hypothermia during sepsis was drawn from the 2005-2012 database of an academic hospital. Hypothermia was defined as body temperature below 36.0 degrees C for longer than 2 h, with at least one reading of 35.5 degrees C or less. The patients presented with 138 episodes of hypothermia, 21 at the time of the sepsis diagnosis and 117 with a later onset. However, hypothermia was uncommon in the final 12 h of life of the patients that succumbed. The majority (97.1%) of the hypothermic episodes were transient and self-limited; the median recovery time was 6 h; body temperature rarely fell below 34.0 degrees C. Bidirectional oscillations in body temperature were evident in the course of hypothermia. Nearly half of the hypothermic episodes had onset in the absence of shock or respiratory distress, and the incidence of hypothermia was not increased during either of these conditions. Usage of antipyretic drugs, sedatives, neuroleptics, or other medications did not predict the onset of hypothermia. In conclusion, hypothermia appears to be a predominantly transient, self-limiting, and nonterminal phenomenon that is inherent to human sepsis. These characteristics resemble those of the regulated hypothermia shown to replace fever in animal models of severe systemic inflammation. (AU)

Processo FAPESP: 14/09576-5 - Desenvolvimento de técnicas estatístico-computacionais para construir, modelar e analisar redes biológicas envolvidas em doenças humanas
Beneficiário:André Fujita
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/03831-8 - Elo entre balanço energético e inflamação sistêmica: papel da leptina
Beneficiário:Alexandre Alarcon Steiner
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
Processo FAPESP: 11/50761-2 - Modelos e métodos de e-Science para ciências da vida e agrárias
Beneficiário:Roberto Marcondes Cesar Junior
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 13/00506-1 - Séries temporais, ondaletas e análise de dados funcionais
Beneficiário:Pedro Alberto Morettin
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 09/15530-0 - Sepse - estudo da resposta inflamatória: sinalização, participação das células do sistema imunológico, tolerância e intervenções terapêuticas
Beneficiário:Francisco Garcia Soriano
Linha de fomento: Auxílio à Pesquisa - Temático