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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Spontaneous hypothermia in human sepsis is a transient, self-limiting, and nonterminal response

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Fonseca, Monique T. [1] ; Rodrigues, Abner C. [2] ; Cezar, Luana C. [1] ; Fujita, Andre [2] ; Soriano, Francisco G. [3] ; Steiner, Alexandre A. [1]
Total Authors: 6
[1] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Applied Physiology; v. 120, n. 12, p. 1394-1401, JUN 15 2016.
Web of Science Citations: 10

Hypothermia in sepsis is generally perceived as something dysregulated and progressive although there has been no assessment on the natural course of this phenomenon in humans. This was the first study on the dynamics of hypothermia in septic patients not subjected to active rewarming, and the results were surprising. A sample of 50 subjects presenting with spontaneous hypothermia during sepsis was drawn from the 2005-2012 database of an academic hospital. Hypothermia was defined as body temperature below 36.0 degrees C for longer than 2 h, with at least one reading of 35.5 degrees C or less. The patients presented with 138 episodes of hypothermia, 21 at the time of the sepsis diagnosis and 117 with a later onset. However, hypothermia was uncommon in the final 12 h of life of the patients that succumbed. The majority (97.1%) of the hypothermic episodes were transient and self-limited; the median recovery time was 6 h; body temperature rarely fell below 34.0 degrees C. Bidirectional oscillations in body temperature were evident in the course of hypothermia. Nearly half of the hypothermic episodes had onset in the absence of shock or respiratory distress, and the incidence of hypothermia was not increased during either of these conditions. Usage of antipyretic drugs, sedatives, neuroleptics, or other medications did not predict the onset of hypothermia. In conclusion, hypothermia appears to be a predominantly transient, self-limiting, and nonterminal phenomenon that is inherent to human sepsis. These characteristics resemble those of the regulated hypothermia shown to replace fever in animal models of severe systemic inflammation. (AU)

FAPESP's process: 11/50761-2 - Models and methods of e-Science for life and agricultural sciences
Grantee:Roberto Marcondes Cesar Junior
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/09576-5 - Development of computational-statistical methods to construct, model and analyze biological networks associated with human diseases
Grantee:André Fujita
Support type: Regular Research Grants
FAPESP's process: 09/15530-0 - Sepsis - the role of inflammatory response: cell signaling; immune system action in sepsis; LPS tolerance and therapeutic
Grantee:Francisco Garcia Soriano
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/03831-8 - Linking energy balance to systemic inflammation: role of leptin
Grantee:Alexandre Alarcon Steiner
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/00506-1 - Time series, wavelets and functional data analysis
Grantee:Pedro Alberto Morettin
Support type: Research Projects - Thematic Grants