Abnormal Cortico-Cerebellar Functional Connectivity in Autism Spectrum Disorder

Autor(es)

Ramos, Taiane Coelho ^[1] ; Balardin, Joana Bisol ^[2] ; Sato, Joao Ricardo ^[3] ; Fujita, Andre ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Math & Stat, Dept Comp Sci, Sao Paulo - Brazil

^[2] Hosp Israelita Albert Einstein, Brain Inst, Sao Paulo - Brazil

^[3] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN SYSTEMS NEUROSCIENCE; v. 12, JAN 15 2019.
• Citações Web of Science: 4

Resumo

The cerebral cortex and the cerebellum are spatially remote areas that are connected by complex circuits that link both primary and associative areas. Previous studies have revealed abnormalities in autism spectrum disorder (ASD); however, it is not clear whether cortico-cerebellar connectivity is differentially manifested in the disorder. To explore this issue, we investigated differences in intrinsic cortico-cerebellar functional connectivity between individuals with typical development (TD) and those with ASD. To this end, we used functional magnetic resonance imaging (fMRI) of 708 subjects under a resting state protocol provided by the ABIDE I Consortium. We found that people with ASD had diminished functional connectivity between the cerebellum and the following cortical regions: (i) right fusiform gyrus, (ii) right postcentral gyrus, (iii) right superior temporal gyrus, (iv) right middle temporal gyrus, and (v) left middle temporal gyrus. All of these regions are involved in many cognitive systems that contribute to commonly affected functions in ASD. For right fusiform gyrus, right superior temporal gyrus, and left middle temporal gyrus, we reproduced the results in an independent cohort composed of 585 subjects of the ABIDE II Consortium. Our results points toward a consistent atypical cortico-cerebellar connectivity in ASD. (AU)

• Processo FAPESP: 16/13422-9 - Métodos estatísticos para grafos com aplicações em ciências da vida
• Beneficiário: André Fujita
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/17996-5 - Estratificação de desordens psiquiátricas utilizando análises discriminante e de agrupamento para redes
• Beneficiário: André Fujita
• Modalidade de apoio: Bolsas no Exterior - Pesquisa
• Processo FAPESP: 13/07375-0 - CeMEAI - Centro de Ciências Matemáticas Aplicadas à Indústria
• Beneficiário: Francisco Louzada Neto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 15/01587-0 - Armazenagem, modelagem e análise de sistemas dinâmicos para aplicações em e-Science
• Beneficiário: João Eduardo Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Programa eScience e Data Science - Temático