| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Univ Sao Paulo, Inst Math & Stat, Dept Comp Sci, Sao Paulo - Brazil
[2] Hosp Israelita Albert Einstein, Brain Inst, Sao Paulo - Brazil
[3] Univ Fed ABC, Ctr Math Computat & Cognit, Santo Andre - Brazil
Total Affiliations: 3
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| Document type: | Journal article |
| Source: | FRONTIERS IN SYSTEMS NEUROSCIENCE; v. 12, JAN 15 2019. |
| Web of Science Citations: | 4 |
| Abstract | |
The cerebral cortex and the cerebellum are spatially remote areas that are connected by complex circuits that link both primary and associative areas. Previous studies have revealed abnormalities in autism spectrum disorder (ASD); however, it is not clear whether cortico-cerebellar connectivity is differentially manifested in the disorder. To explore this issue, we investigated differences in intrinsic cortico-cerebellar functional connectivity between individuals with typical development (TD) and those with ASD. To this end, we used functional magnetic resonance imaging (fMRI) of 708 subjects under a resting state protocol provided by the ABIDE I Consortium. We found that people with ASD had diminished functional connectivity between the cerebellum and the following cortical regions: (i) right fusiform gyrus, (ii) right postcentral gyrus, (iii) right superior temporal gyrus, (iv) right middle temporal gyrus, and (v) left middle temporal gyrus. All of these regions are involved in many cognitive systems that contribute to commonly affected functions in ASD. For right fusiform gyrus, right superior temporal gyrus, and left middle temporal gyrus, we reproduced the results in an independent cohort composed of 585 subjects of the ABIDE II Consortium. Our results points toward a consistent atypical cortico-cerebellar connectivity in ASD. (AU) | |
| FAPESP's process: | 16/13422-9 - Statistical methods in graphs with applications to life sciences |
| Grantee: | André Fujita |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/17996-5 - Stratification of psychiatric disorders by using network discriminant and clustering analyses |
| Grantee: | André Fujita |
| Support Opportunities: | Scholarships abroad - Research |
| FAPESP's process: | 13/07375-0 - CeMEAI - Center for Mathematical Sciences Applied to Industry |
| Grantee: | Francisco Louzada Neto |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 15/01587-0 - Storage, modeling and analysis of dynamical systems for e-Science applications |
| Grantee: | João Eduardo Ferreira |
| Support Opportunities: | Research Grants - eScience and Data Science Program - Thematic Grants |