Polyphenols from food by-products: An alternative or complementary therapy to IBD conventional treatments

Autor(es)

Machado, Ana Paula da Fonseca ^[1] ; Geraldi, Marina Vilar ^[1] ; Nascimento, Roberto de Paula do ^[1] ; Moya, Amanda Maria Tomazini Munhoz ^[1] ; Vezza, Teresa ^[2] ; Diez-Echave, Patricia ^[2] ; Juan Galvaz, Julio ^[2] ; Cazarin, Cinthia Bau Betim ^[1] ; Marostica Junior, Mario Roberto ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Food Engn, 80 Monteiro Lobato St, BR-13083862 Campinas, SP - Brazil

^[2] Univ Granada, Inst Biosanit Res Granada Ibs GRANADA, Biomed Res Ctr CIBM, Dept Pharmacol, CIBER EHD, Campus Salud, Granada 18071 - Spain

• Tipo de documento: Artigo Científico
• Fonte: Food Research International; v. 140, FEB 2021.
• Citações Web of Science: 2

Resumo

Inflammatory bowel diseases (IBD) are illnesses characterized by chronic intestinal inflammation and microbial dysbiosis that have emerged as a public health challenge worldwide. It comprises two main conditions: Crohn's disease and ulcerative colitis. Currently, conventional therapy to treat IBD are not free from side effects, such as liver and kidney toxicity, drug resistance, and allergic reactions. In view of this, there is growing research for alternative and complementary therapies that, in addition to acting in the prevention or the control of the disease, do not compromise the quality of life and health of individuals. In this sense, a growing body of evidence has confirmed the benefits of natural phenolic compounds in intestinal health. Phenolic compounds or poly phenols are molecules widely distributed throughout the plant kingdom (flowers, vegetables, leaves, and fruits), including plant materials remaining of the handling and food industrial processing, referred to in the scientific literature as by-products, food waste, or bagasse. Since by-products are low-cost, abundant, easily accessible, safe, and rich in bioactive compounds, it becomes an exciting option to extract, concentrate or isolate phenolic compounds to be posteriorly applied in the therapeutic approach of IBD. In this article, we have reviewed the main phenolic compounds present in various plants and by-products that have shown beneficial and/or promising effects in experimental pre-clinical, clinical, and in vitro research with IBD. In addition, we have mentioned and suggested several plants and by-products originated and produced in Latin America that could be part of future research as good sources of specific phenolic compounds to be applied in the prevention and development of alternative treatments for IBD. This review may offer a valuable reference for studies related to IBD administering phenolic compounds from natural, cheap, and easily accessible raw and undervalued materials. (AU)

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