Plants from the genus Eugenia as promising therapeutic agents for the management of diabetes mellitus: A review

Autor(es)

Araujo, Nayara Macedo Peixoto ^[1] ; Arruda, Henrique Silvano ^{[1, 2]} ; Farias, David de Paulo ^[1] ; Molina, Gustavo ^[3] ; Pereira, Gustavo Araujo ^[4] ; Pastore, Glaucia Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Campinas UNICAMP, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80, POB 13083-862, BR-13083862 Campinas, SP - Brazil

^[2] Univ Campinas UNICAMP, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, BR-13083862 Campinas, SP - Brazil

^[3] Univ Fed Vales Jequitinhonha & Mucuri, Inst Sci & Technol, Food Engn, BR-39100000 Diamantina, MG - Brazil

^[4] Fed Univ Para UFPA, Inst Technol, Sch Food Engn, BR-66075110 Belem, Para - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Food Research International; v. 142, APR 2021.
• Citações Web of Science: 0

Resumo

This review combined scientific data regarding the use of genus Eugenia plants for the management of diabetes. Diabetes mellitus is a chronic metabolic disease mainly characterized by hyperglycaemia, which can lead to serious health complications. Scientists have been seeking therapeutic compounds in plants, reporting the species of the genus Eugenia as a potential source of phytochemicals with antidiabetic properties. In vitro and in vivo studies have proved that the bioactive compounds in the genus Eugenia can positively affect the biomarkers of diabetes. We discussed the phytochemical profile of the genus Eugenia and its mechanism of action on diabetes, which could modulate carbohydrate metabolism, glucose homeostasis, and insulin secretion, inhibit carbohy-drases and reduce oxidative stress, suppressing the formation of advanced glycation end-products and protect-ing/regenerating pancreatic beta-cells. Therefore, plants of the genus Eugenia showed therapeutic potential to be used in the treatment of diabetes and its comorbidities. (AU)

• Processo FAPESP: 20/00225-6 - Determinação do potencial antioxidante, bioacessibilidade in vitro e avaliação das atividades antidiabética e prebiótica da uvaia (Eugenia pyriformis Cambess)
• Beneficiário: David de Paulo Farias
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 18/10608-0 - Identificação dos compostos bioativos da Pitanga do Cerrado (Eugenia calycina Cambess) e estudo das suas atividades biológicas
• Beneficiário: Nayara Macedo Peixoto
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 15/50333-1 - Cobra: nova plataforma de descoberta de compostos para identificação rápida e de baixo custo de bioativo com efeitos benéficos originários de plantas brasileiras
• Beneficiário: Glaucia Maria Pastore
• Modalidade de apoio: Auxílio à Pesquisa - Temático