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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Plants from the genus Eugenia as promising therapeutic agents for the management of diabetes mellitus: A review

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Author(s):
Araujo, Nayara Macedo Peixoto [1] ; Arruda, Henrique Silvano [1, 2] ; Farias, David de Paulo [1] ; Molina, Gustavo [3] ; Pereira, Gustavo Araujo [4] ; Pastore, Glaucia Maria [1]
Total Authors: 6
Affiliation:
[1] Univ Campinas UNICAMP, Sch Food Engn, Dept Food Sci, Bioflavors & Bioact Cpds Lab, Monteiro Lobato St 80, POB 13083-862, BR-13083862 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Sch Food Engn, Dept Food & Nutr, Nutr & Metab Lab, BR-13083862 Campinas, SP - Brazil
[3] Univ Fed Vales Jequitinhonha & Mucuri, Inst Sci & Technol, Food Engn, BR-39100000 Diamantina, MG - Brazil
[4] Fed Univ Para UFPA, Inst Technol, Sch Food Engn, BR-66075110 Belem, Para - Brazil
Total Affiliations: 4
Document type: Review article
Source: Food Research International; v. 142, APR 2021.
Web of Science Citations: 0
Abstract

This review combined scientific data regarding the use of genus Eugenia plants for the management of diabetes. Diabetes mellitus is a chronic metabolic disease mainly characterized by hyperglycaemia, which can lead to serious health complications. Scientists have been seeking therapeutic compounds in plants, reporting the species of the genus Eugenia as a potential source of phytochemicals with antidiabetic properties. In vitro and in vivo studies have proved that the bioactive compounds in the genus Eugenia can positively affect the biomarkers of diabetes. We discussed the phytochemical profile of the genus Eugenia and its mechanism of action on diabetes, which could modulate carbohydrate metabolism, glucose homeostasis, and insulin secretion, inhibit carbohy-drases and reduce oxidative stress, suppressing the formation of advanced glycation end-products and protect-ing/regenerating pancreatic beta-cells. Therefore, plants of the genus Eugenia showed therapeutic potential to be used in the treatment of diabetes and its comorbidities. (AU)

FAPESP's process: 20/00225-6 - Determination of antioxidant potential, in vitro bioaccessibility and evaluation of antidiabetic and prebiotic activities from the uvaia (Eugenia pyriformis Cambess)
Grantee:David de Paulo Farias
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 18/10608-0 - Identification of bioactive compounds from Pitanga do Cerrado (Eugenia calycina Cambess) and study of its biological activities
Grantee:Nayara Macedo Peixoto
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 15/50333-1 - COBRA: a novel compound discovery pipeline for rapid and cost-effective identification of bioactives with health beneficial effects in Brazilian crops
Grantee:Glaucia Maria Pastore
Support Opportunities: Research Projects - Thematic Grants