Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways

Autor(es):Mostrar menos -

Silva Mancini, Mariana Camargo ^[1] ; Saboia Ponte, Luis Gustavo ^[1] ; Rocha Silva, Cayo Henrique ^[1] ; Fagundes, Isabella ^[1] ; Betim Pavan, Isadora Carolina ^{[1, 2]} ; Romeiro, Stefhani Andrioli ^[1] ; Salvino da Silva, Luiz Guilherme ^[1] ; Morelli, Ana Paula ^[1] ; Rostagno, Mauricio Ariel ^[1] ; Simabuco, Fernando Moreira ^[1] ; Neves Bezerra, Rosangela Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Appl Sci FCA, Multidisciplinary Lab Food & Hlth LabMAS, UNICAMP, Limeira - Brazil

^[2] Univ Estadual Campinas, Sch Pharmaceut Sci FCF, Lab Signal Mech, UNICAMP, Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Phytotherapy Research; v. 35, n. 9, p. 5241-5258, SEP 2021.
• Citações Web of Science: 1

Resumo

Beet (Beta vulgaris L.) has high nutritional value, containing bioactive compounds such as betalains and flavonoids. Scientific evidence points to the use of these natural compounds in the treatment of several types of cancer, such as prostate cancer, one of the main causes of morbidity and mortality in men. Here, we compared beet roots and leaves extracts, and their main compounds, apigenin, and betanin, respectively, in DU-145 and PC-3 prostate cancer cell lines. Both cells presented the proliferation decreased for beetroot and beet leaves extracts. The apigenin treatment also reduced the proliferation of both cell lines. Regarding cell migration, beet leaves extract was able to decrease the scratch area in both cell lines, whereas apigenin affected only PC-3 cells' migration. In colony formation assay, both extracts were effective in reducing the number of colonies formed. Besides, the beet leaves extracts and apigenin presented strong inhibition of growth-related signaling pathways in both cell lines, and the beetroot extract and betanin presented effects only in DU-145 cells. Furthermore, the extracts and isolated compounds were able to reduce the levels of apoptotic and cell cycle proteins. This study reveals that beet extracts have important anti-cancer effects against prostate cancer cells. (AU)

• Processo FAPESP: 19/13848-4 - Avaliação de compostos naturais derivados da beterraba em células do câncer do colo do útero HeLa
• Beneficiário: Stefhani Andrioli Romero
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 18/14818-9 - Estudo de alvos moleculares importantes para o controle do metabolismo em câncer: a via da mTOR/S6K com papel central
• Beneficiário: Fernando Moreira Simabuco
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores - Fase 2
• Processo FAPESP: 16/06457-0 - Folhas e talos de beterraba (Beta vulgaris L.): caracterização e efeitos da capacidade antioxidante em indivíduos obesos e dislipidêmicos
• Beneficiário: Rosângela Maria Neves Bezerra
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/00311-1 - Caracterização funcional de proteínas de interação das diferentes isoformas de S6Ks
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• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 19/00607-9 - Caracterização de alvos moleculares envolvidos na resistência quimioterápica e no metabolismo tumoral de células de câncer de pulmão
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• Modalidade de apoio: Bolsas no Brasil - Mestrado