Development of silver nanoparticles coated with silicon dioxide and their application in experimental dental composites

• Grant number: 17/22999-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2018
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Marcela Charantola Rodrigues
• Grantee: Marcela Charantola Rodrigues
• Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Cruzeiro do Sul (UNICSUL). São Paulo , SP, Brazil
• Associated researchers: Amedea Barozzi Seabra ; Bruno Bueno Silva ; Roberto Ruggiero Braga

Abstract

The aims of this study is 1) to synthesize and characterize silver nanoparticles coated with silicone dioxide, with the purpose of masking the metallic coloration of silver, and 2) to evaluate the effect of these particles in a experimental resin-based materials for the antimicrobial activity, degree of conversion, optical and mechanical properties. Materials and Methods: in the first part of the study silver nanoparticles coated with silicon dioxide will be synthesized and characterized. In the second part of the project, these particles will be incorporated in an organic matrix containing BisGMA and TEGDMA (1:1 in mols) to be evaluated for antimicrobial activity (minimum inhibitory concentration and biofilm formation). The materials showing significant antimicrobial activity against Streptococcus mutans will be tested for degree of conversion (FTIR spectroscopy), optical properties in spectrophotometry (total transmittance and ”E) and mechanical properties (biaxial flexural strength and elastic modulus). In finding homoscedastic results in the second phase, it will be applied the ANOVA followed by Tukey's Test to contrast among means, at a significance level of 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, MARCELA CHARANTOLA; ROLIM, WALLACE ROSADO; VIANA, MARINA MARIANTE; SOUZA, THAIS RODRIGUES; GONCALVES, FLAVIA; TANAKA, CAIO JUNJI; BUENO-SILVA, BRUNO; SEABRA, AMEDEA BAROZZI. Biogenic synthesis and antimicrobial activity of silica-coated silver nanoparticles for esthetic dental applications. Journal of Dentistry, v. 96, MAY 2020. (14/50906-9, 17/22999-0, 18/08194-2)