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Experimental infection of neotropical bats with Hantavirus

Grant number: 18/50016-4
Support type:Regular Research Grants
Duration: June 01, 2018 - May 31, 2020
Field of knowledge:Biological Sciences - Microbiology
Cooperation agreement: Texas Tech University
Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
Principal Investigator:Luiz Tadeu Moraes Figueiredo
Grantee:Luiz Tadeu Moraes Figueiredo
Principal investigator abroad: Jorge Salazar-Bravo
Institution abroad: Texas Tech University (TTU), United States
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:14/02438-6 - Studies with Bunyaviridae that produce human disease, AP.TEM

Abstract

Until 2012 there was only one report of hantavirus in bats, in which have described an isolation of a pathogenic hantavirus: Hantaan virus (HTNV) in lung tissues of bats. After this unique fact, all hantaviruses reported in bats were not related with human disease, however, there were evidences of a lethal genotype of Andes virus, the Araraquara virus (ARQV) among Neotropical bats in Brazil. Therefore, it is proposed here to study, experimentally, the infection and its kinetics, the immune-pathogenesis infection process in Neotropical bats. This research will be divided in (I) maintenance of Neotropical bats such as Carollia perspicillata and Desmodus rotundus; (II) experimental infection of theses bats with hantavirus in our BSL-3 facility, (III) evaluate the kinetics of infection and immune-pathogenesis; (IV) isolation and deep sequencing hantaviruses in excreta and organ tissues; (V) study the evolution and phylogeny of theses hantaviruses in comparison of those in wild rodents and others bats hantaviruses. Thus, we intend to understand the dynamics of infections in nature and if Neotropical bats are disseminating these lethal viruses. (AU)

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