| Grant number: | 18/03673-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | August 01, 2018 |
| End date: | June 30, 2020 |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Daniel Martins-de-Souza |
| Grantee: | Daniel Martins-de-Souza |
| Host Institution: | Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
| City of the host institution: | Campinas |
| Associated scholarship(s): | 19/03271-1 - Proteome modulation by cannabinoid drugs in human oligodendrocytes, BP.TT |
Abstract
nd to discover possible therapeutic agents for this process. Studies indicate that the modulation of the endocannabinoid system in oligodendrocytes can affect important biological processes. Thus, the aim of this project will evaluate several pharmacological manipulations of the endocannabinoid system in human culture of oligodendrocytes (MO3.13), and in the differentiation process of these cells. These investigations may elucidate aspects of disorders with demyelinating processes, such as multiple sclerosis and schizophrenia. More specifically, studies have shown the involvement of the endocannabinoid system and oligodendrocytes in the pathophysiology of this schizophrenia. Thus, we will investigate the possible relationships between these two components. For this, MO3.13 culture cell will be treated with MK801 (NMDAr antagonist), which has been an in vitro model to study schizophrenia proposed by our group. We hope to identify the proteins and biochemical pathways affected by cannabinoids in immature and mature cells treated or not with MK801, as well as the influence on the differentiation process. Additionally, we will evaluate the effects of cannabinoids on cuprizone-induced demyelination in vtiro. For this, proteomic and molecular biology will be used. Finally, this study may contribute to the understanding of the role of the endocannabinoid system in oligodendrocytes and the possible implications for elucidating aspects of the pathophysiology of the demyelinating process and more specifically in the context of schizophrenia. (AU)
| Articles published in Agência FAPESP Newsletter about the research grant: |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |