The role of microRNAs in metabolic alterations promoted by diet-induced obesity or maternal obesity

• Grant number: 18/07087-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: October 31, 2020
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Alice Cristina Rodrigues
• Grantee: Alice Cristina Rodrigues
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Da Zhi Wang

Abstract

Obesity, defined as chronically unbalanced energy intake relative to its expenditure, resulting in lipid accumulation in adipose tissue, is a multifactorial disease, influenced by genetic, environmental and behavioral factors. Although diet and sedentarism, risk factor for obesity, are modifiable factors, others factors are no-modifiable, such as genetics factors, or as animal's studies have suggested, epigenetics mechanisms programmed in utero. Compelling evidences suggests microRNAs, small non-coding RNAS, are important in the development of obesity, both from maternal inheritance or diet-induced. Moreover, studies with humans and murines has shown therapeutic strategies, such as aerobic physical exercise, modulate circulating microRNAs and in adipose tissue. In light of this, using two models of obesity, diet-induced or maternal inheritance, our aim is to study the participation of microRNAs in the development of obesity. Aerobic training will be used in the second part of the study so that we might understand the participation of microRNAs in strategies that mitigate obesity. The results obtained in the present project will contribute to our better understanding of the molecular mechanisms of obesity, and will suggest microRNAs as targets for therapeutic intervention in obesity (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FALQUETTO, BARBARA; THIEME, KARINA; MALTA, MARILIA B.; ROCHA, KARINA C. E.; TUPPY, MARINA; POTJE, SIMONE R.; ANTONIALI, CRISTINA; RODRIGUES, ALICE C.; MUNHOZ, CAROLINA D.; MOREIRA, THIAGO S.; et al. Oxidative stress in the medullary respiratory neurons contributes to respiratory dysfunction in the 6-OHDA model of Parkinson's disease. JOURNAL OF PHYSIOLOGY-LONDON, v. 598, n. 22, SEP 2020. (19/01236-4, 18/05426-0, 19/00065-1, 18/07087-8, 16/03572-3, 15/23376-1, 15/11268-0)

DE MENDONCA, MARIANA; ROCHA, KARINA C.; DE SOUSA, ERICA; PEREIRA, BEATRIZ M., V; OYAMA, LILA MISSAE; RODRIGUES, ALICE C.. Aerobic exercise training regulates serum extracellular vesicle miRNAs linked to obesity to promote their beneficial effects in mice. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, v. 319, n. 3, p. 13-pg., 2020-09-01. (18/05426-0, 18/07087-8, 16/08202-0, 17/19513-9)

DA PAIXAO, AILMA O.; BOLIN, ANAYSA PAOLA; SILVESTRE, JOAO G.; RODRIGUES, ALICE CRISTINA. Palmitic Acid Impairs Myogenesis and Alters Temporal Expression of miR-133a and miR-206 in C2C12 Myoblasts. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 5, MAR 2021. (15/24789-8, 18/07087-8, 20/08049-2)

RODRIGUES, ALICE C.; SPAGNOL, ALEXANDRE R.; FRIAS, FLAVIA DE TOLEDO; DE MENDONCA, MARIANA; ARAUJO, HYGOR N.; GUIMARAES, DIMITRIUS; SILVA, WILLIAM J.; BOLIN, ANAYSA PAOLA; MURATA, GILSON MASAHIRO; SILVEIRA, LEONARDO. ntramuscular Injection of miR-1 Reduces Insulin Resistance in Obese Mic. FRONTIERS IN PHYSIOLOGY, v. 12, JUL 6 2021. (20/08049-2, 11/05876-6, 17/19513-9, 18/07087-8, 18/07241-7, 15/24789-8)