Reducing gait deficits with model-driven functional electrical stimulation

• Grant number: 18/04964-8
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: April 30, 2022
• Field of knowledge: Health Sciences - Physical Education
• Agreement: West Virginia University
• Principal Investigator: Ana Maria Forti Barela
• Grantee: Ana Maria Forti Barela
• Principal researcher abroad: Valeriya Gritsenko
• Institution abroad: West Virginia University (WVU), United States
• Host Institution: Pró-Reitoria de Pós-Graduação e Pesquisa. Universidade Cruzeiro do Sul (UNICSUL). São Paulo , SP, Brazil
• Associated researchers: José Angelo Barela ; Sergiy Yakovenko
• Associated scholarship(s): 21/09948-3 - Development of a portable functional electrical stimulator using an H bridge, current source, and feedback for closed loop control during gait of individuals with stroke, BP.TT; 20/05323-6 - Implementation of portable functional stimulator using an H bridge, current source and feedback for closed loop control at specific gait phases in individuals with hemiparesis due to stroke, BP.TT

Abstract

The main goal of this project is to develop a novel rehabilitation paradigm using functional electrical stimulation (FES) driven by a dynamical model of the human lower limb. We will use the model to assess the changes in active muscle forces that lead to the limited knee flexion in the paretic limb as post-stroke individuals walk. In the first year of the project, we will assess the overground and treadmill gait of post-stroke individuals and healthy individuals with and without knee restriction at Cruzeiro do Sul and West Virginia universities respectively. We will also develop a musculoskeletal dynamical (MSD) model of lower-limbs and compute muscle forces from data collected at both universities. In the second year of the project, we will develop strategies for gait intervention with FES. Researchers from Cruzeiro do Sul University will assess overground gait of post-stroke individuals walking with FES, and the researchers from West Virginia University will assess gait on a treadmill with and without FES for the validation of MSD model. We expect to show how a reduced knee flexion deficit post stroke results from the abnormal pattern of muscle activity and co-contraction that lead to a reduced active joint torque around the knee and increased joint stiffness. We further expect to show that altering the activity of different muscle groups at different times of the gait cycle in the MSD model will affect the knee angle in a predictable manner. This will instruct the most optimal FES paradigm that will improve the knee flexion of the paretic limb. This will test the potential of model-driven FES to reduce gait deficits after a stroke. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CELESTINO, MELISSA L.; VAN EMMERIK, RICHARD; BARELA, JOSE A.; BACCA, ODAIR; BARELA, ANA M. F.. Effects of limited knee flexion movement in intra-limb gait coordination. JOURNAL OF BIOMECHANICS, v. 128, NOV 9 2021. (16/08883-7, 15/13100-9, 18/04964-8)

BAHDASARIANTS, SERHII; BARELA, ANA MARIA FORTI; GRITSENKO, VALERIYA; BACCA, ODAIR; BARELA, JOSE ANGELO; YAKOVENKO, SERGIY. Does joint impedance improve dynamic leg simulations with explicit and implicit solvers?. PLoS One, v. 18, n. 7, p. 18-pg., 2023-07-03. (18/04964-8)

BACCA, ODAIR; CELESTINO, MELISSA LEANDRO; BARELA, JOSE ANGELO; YAKOVENKO, SERGIY; DE LIMA, ANA JULIA SILVA; BARELA, ANA MARIA FORTI. Compensatory Strategies Due to Knee Flexion Constraint during Gait of Non-Disabled Adults. JOURNAL OF MOTOR BEHAVIOR, JUL 2021. (19/10801-7, 18/04964-8)