Acromegaly: mineral density, microarquitecture and bone strength before and after treatment with biphosphonate NEW TITLE: Bone microarchitecture and strength evaluation in adults with diagnosis of acromegaly

• Grant number: 16/23765-0
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Raquel Soares Jallad
• Grantee: Raquel Soares Jallad
• Host Institution: Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Felipe Henning Gaia Duarte ; Marcello Delano Bronstein ; Paula Paes Batista da Silva ; Regina Matsunaga Martin ; Rosa Maria Rodrigues Pereira

Abstract

Several population studies identified risk factors of fractures such as age, history of fracture, gonadal function and bone mineral density. Recently, the literature has indicated that bone microarchitecture should also be considered as an independent risk factor for fracture and bone strength.Patients with acromegaly represents a population with a high potential for vertebral fractures and reduced bone mineral density (BMD) in some places, especially when associated with multiple pituitary hormone deficiency.Studies evaluating bone microarchitecture in acromegaly are scarce. Thus, this study provides the opportunity to assess bone microarchitecture and strengh biochemical in acromegaly as well as the impact of treating the disease and / or osteoporosis in this parameter. Eventually, these data can allow the early diagnosis of the risk of fracture, as well as better therapeutic strategy to minimize the occurrence of fractures (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BORBA HERKENHOFF, CLARISSA G.; TRARBACH, ERICKA B.; BATISTA, RAFAEL LOCH; SOARES, IBERE CAUDURO; FRASSETTO, FERNANDO PEREIRA; PEREIRA DO NASCIMENTO, FELIPE BARJUD; PAJARO GRANDE, ISABELLA PACETTI; SILVA, PAULA P. B.; DUARTE, FELIPE H. G.; BRONSTEIN, MARCELLO D.; et al. Survivin: A Potential Marker of Resistance to Somatostatin Receptor Ligands. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. N/A, p. 12-pg., 2022-10-24. (16/23765-0)

SILVA, PAULA P. B.; PEREIRA, ROSA M. R.; TAKAYAMA, LILIAM; BORBA, CLARISSA G.; DUARTE, FELIPE H.; TRARBACH, ERICKA B.; MARTIN, REGINA MATSUNAGA; BRONSTEIN, MARCELLO D.; TRITOS, NICHOLAS A.; JALLAD, RAQUEL S.. Impaired Bone Microarchitecture in Premenopausal Women With Acromegaly: The Possible Role of Wnt Signaling. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, v. 106, n. 9, p. 2690-2706, SEP 2021. (16/23765-0)