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Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II

Grant number: 03/02176-7
Support type:BIOTA-FAPESP Program - Thematic Grants
Duration: November 01, 2004 - September 30, 2010
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:Vanderlan da Silva Bolzani
Grantee:Vanderlan da Silva Bolzani
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Co-Principal Investigators:Massuo Jorge Kato ; Maysa Furlan ; Norberto Peporine Lopes
Associated scholarship(s):10/17329-7 - NuBBE natural products, micromolecular diversity useful for the rational design of novel anticancer agents, BP.DR
10/09780-0 - Mass spectrometry and nuclear magnetic resonance in metabolomic assessment & identification of prototypes of AChE inhibitors in Banisteriopsis variabilis (b. gates) - Malpighiaceae, BP.DR
10/07564-9 - Study of Chrysobalanaceae species with cytotoxic activities: metabolomic analysis for the understanding of sinergistic associations and their micromolecular complexity, BP.DR
+ associated scholarships 09/02648-2 - Study of Jatropha gossypifolia and J. multifida (Euphorbiaceae), using in silico and dereplication methods aiming the detection and in situ elucidation of acetylcholonesterasic, wound healing and antioxidant micromolecules, BP.MS
08/58877-7 - Phylogenetic analyses and study of phenylpropanoid metabolism in Piper species, BP.DR
09/05098-3 - Influence of physical-chemical factors for the racemization of benzopyrans from Peperomia obtusifolia (Piperaceae), BP.IC
09/00940-8 - Qualitative study of polar metabolites from inflorescences of calendula (Calendula officinalis L., Calendulae, Asteraceae): evaluation of different cultivation conditions, BP.IC
08/07380-5 - Development of dereplication analytical methods for metabolomic studies of Qualea species(Vochysiacae): detection and in situ elucidation of potential antioxidant and antimalarial micromolecules, BP.MS
08/51674-3 - Secondary metabolites of Piper reticulatum L., BP.MS
08/01796-5 - In silico detection, isolation and characterization of the antimalarial and antioxidant micromolecular constituents from stems and leaves of Garcinia gardneriana (Clusiaceae), BP.MS
07/57991-8 - Molecular hybridization as a tool to obtain thio pyridine derivatives as acetylcholinesterase inhibitors, BP.MS
06/61586-9 - Biosynthetic study of secolignans in Peperomia glabella var. nervulosa, BP.IC
06/61795-7 - Application of mass spectrometry for the identification of HIV-1 protease inhibitors in plants from Cerrado and Atlantic Rainforest: a modern enzymatic tool for searching new therapeutic agents using the dereplication methodology, BP.PD
06/52363-6 - Bioprospection in species of Piperaceae, BP.MS
06/61187-7 - Bioguided fractionation for selection of potential antioxidant, antimalarial and antibiotic substances in Kielmeyera variabilis (Clusiaceae) and Brosimum glaziovii (Moraceae) species , BP.DR
06/59555-8 - Chemical and biological study of natural cromenes in species of Piperaceae and their analogues, BP.MS
06/54948-1 - Studies of the biosynthetic paths of piperidine alkaloids of Senna spectabilis, BP.DR
06/50086-5 - Characterization of prenyltransferase of Piper crassinervium and gaudichaudianum (Piperaceae), BP.PD
06/51832-2 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II, BP.TT
05/58796-9 - Synthesis and biosynthesis of piperidinyl amides: determination of the activity of the oxydoreductase enzyme of the p450 cytochrome type in Piper tuberculatum, BP.MS
05/58626-6 - Phytochemical study of different organs of Casearia silvestres, BP.IC
05/56500-5 - Biochemical investigation of polar secondary metabolites present in the leaves of Casearia sylvestris SW, BP.IC
05/56404-6 - Synthesis of thioureas analagous to guandine alkaloids obtained from Pterogyne nitens (Leguminosae) with potential antitumoral action, BP.IC
05/54134-1 - Characterization of the prenyltransferase of Piper aduncum (Piperaceae), BP.PD
05/53877-0 - Systematic evaluation of the phytochemical profile of extracts of Lychnophora as a routine method for the preliminary identification of several metabolites of substances by chromate, BP.PD
04/13669-7 - Analysis of the distribution and effect of seasonality on the production of piperidine alkaloids in Senna spectabilis, BP.DR
04/14421-9 - Synthesis and biosynthesis of pyrrolidinic amides: determination of the activity of the oxydoreductase of the p450 cytochrome type in Piper arboreum, BP.IC
04/11982-0 - Peptides of Jatropha spp and of Palicourea marcgravii St. Hill. from the Cerrado and the Atlantic Rainforest: prospection, isolation, structural elucidation and biological activity, BP.MS
04/09547-3 - Study of the proteome with genomic insertion of the 4-nerolidilcatecol in Potomorphe umbellata (Piperaceae), BP.PD - associated scholarships

Abstract

The main goal of this project is to search lead molecules from plant species and endophytic fungi occurring in the state of São Paulo, especially in the Cerrado and Atlantic Forest. The project was conceived to identify antioxidant, anti-inflammatory, antifungal, anticancer, antimalarial and acetylcholinesterase inhibition lead compounds from plant species of these biomes. With a strong multi-disciplinary relationship, this is the second phase of the bioprospecting program, initiated four years ago, when Biota-FAPESP was created as a permanent FAPESP's Program. Besides the main goals on drug discovery, biodiversity conservation, and sustainable economic growth, this project also is supported on advanced natural product chemistry knowledge such as: to evaluate, correlate and develop chemical methodologies to study intra- and inter-specific variability in some selected bioactive species; to develop micropropagation and cell cultures of rare plants producing active compounds;to study biosynthetic pathways and particularly determine the activity of phenyltransferases, terpene cyclases and cytochrome P-450 oxido-reductases, for kinetic studies and further proteomic and functional analysis. This should lead to the cloning of genes that eventually can be used for recombinatorial biosynthesis of heterolgous overexpression in other plants; to conduct studies on structure activity relationships (SAR) of some lead compounds previously identified; to sustain and maintain the virtual database (datamine) already initiated in phase I. (AU)

Scientific publications (65)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHAPLA, VANESSA M.; ZERAIK, MARIA L.; CAFEU, MARIANA C.; SILVA, GERALDO H.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; YOUNG, MARIA C. M.; PFENNING, LUDWIG H.; ARAUJO, ANGELA R. Griseofulvin, Diketopiperazines and Cytochalasins from Endophytic Fungi Colletotrichum crassipes and Xylaria sp., and Their Antifungal, Antioxidant and Anticholinesterase Activities. Journal of the Brazilian Chemical Society, v. 29, n. 8, p. 1707-1713, AUG 2018. Web of Science Citations: 0.
The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. Anais da Academia Brasileira de Ciências, v. 90, n. 1, p. -, 2018.
The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. Anais da Academia Brasileira de Ciências, n. ahead, p. -, 2018.
VALLI, MARILIA; RUSSO, HELENA M.; BOLZANI, VANDERLAN S. The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 763-778, 2018. Web of Science Citations: 1.
VIEIRA, JR., GERARDO MAGELA; DUTRA, LUIZ A.; TORRES, ROSELI B.; BORALLE, NIVALDO; BOLZANI, VANDERLAN DA S.; SIQUEIRA SILVA, DULCE H.; CHAVES, MARIANA H.; CAVALHEIRO, ALBERTO J. Chemical constituents from Casearia spp. (Flacourtiaceae/Salicaceae sensu lato). REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 27, n. 6, p. 785-787, NOV-DEC 2017. Web of Science Citations: 0.
PILON, ALAN C.; VALLI, MARILIA; DAMETTO, ALESSANDRA C.; PINTO, MERI EMILI F.; FREIRE, RAFAEL T.; CASTRO-GAMBOA, IAN; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN S. NuBBE(DB): an updated database to uncover chemical and biological information from Brazilian biodiversity. SCIENTIFIC REPORTS, v. 7, AUG 3 2017. Web of Science Citations: 12.
SILVA, GERALD H.; ZERAIK, MARIA L.; DE OLIVEIRA, CAMILA M.; TELES, HELDER L.; TREVISAN, HENRIQUE C.; PFENNING, LUDWIG H.; NICOLLI, CAMILA P.; YOUNG, MARIA C. M.; MASCARENHAS, YVONNE P.; ABREU, LUCAS M.; SARAIVA, AMANDA C.; MEDEIROS, ALEXANDRA I.; BOLZANI, VANDERLAN DA S.; ARAUJO, ANGELA R. Lactone Derivatives Produced by a Phaeoacremonium sp., an Endophytic Fungus from Senna spectabilis. Journal of Natural Products, v. 80, n. 5, p. 1674-1678, MAY 2017. Web of Science Citations: 4.
MARILIA VALLI; WANESSA ALTEI; RICARDO N. DOS SANTOS; EMILIO C. DE LUCCA JR.; MARCO A. DESSOY; RENAN M. PIOLI; FERNANDO COTINGUIBA; XAVIER CACHET; SYLVIE MICHEL; MAYSA FURLAN; LUIZ C. DIAS; ADRIANO D. ANDRICOPULO; VANDERLAN S. BOLZANI. Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration. Journal of the Brazilian Chemical Society, v. 28, n. 3, p. 475-484, Mar. 2017.
VALLI, MARILIA; ALTEI, WANESSA; DOS SANTOS, RICARDO N.; DE LUCCA, JR., EMILIO C.; DESSOY, MARCO A.; PIOLI, RENAN M.; COTINGUIBA, FERNANDO; CACHET, XAVIER; MICHEL, SYLVIE; FURLAN, MAYSA; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN S. Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor of Breast Cancer Cell Line Migration. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 475-484, MAR 2017. Web of Science Citations: 5.
JULIANA R. GUBIANI; HELDER L. TELES; GERALDO H. SILVA; MARIA CLÁUDIA M. YOUNG; JOSÉ O. PEREIRA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. CYCLO-(TRP-PHE) DIKETOPIPERAZINES FROM THE ENDOPHYTIC FUNGUS Aspergillus versicolor ISOLATED FROM Piper aduncum#. Química Nova, v. 40, n. 2, p. 138-142, Fev. 2017. Web of Science Citations: 0.
COQUEIRO, ALINE; CHOI, YOUNG H.; VERPOORTE, ROBERT; GUPTA, KARTHICK B. S. S.; DE MIER, MARIA; HAMBURGER, MATTHIAS; YOUNG, MARIA C. M.; STAPLETON, PAUL; GIBBONS, SIMON; BOLZANI, VANDERLAN DA S. Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis. Journal of Natural Products, v. 79, n. 3, p. 470-476, MAR 2016. Web of Science Citations: 7.
NETO, FAUSTO CARNEVALE; PILON, ALAN C.; SELEGATO, DENISE M.; FREIRE, RAFAEL T.; GU, HAIWEI; RAFTERY, DANIEL; LOPES, NORBERTO P.; CASTRO-GAMBOA, IAN. Dereplication of Natural Products Using GC-TOF Mass Spectrometry: Improved Metabolite Identification by Spectral Deconvolution Ratio Analysis. FRONTIERS IN MOLECULAR BIOSCIENCES, v. 3, 2016. Web of Science Citations: 4.
TAJIMA, YASUHIRO; MURASE, HAYATO; SATAKE, KAZUHIRO; MITANI, YUJI; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; EFFERTH, THOMAS; NAKAGAWA, HIROSHI. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, induces osteoclastic cell death. Cytotechnology, v. 67, n. 4, SI, p. 585-592, AUG 2015. Web of Science Citations: 3.
VALLI, MARILIA; BETTI, ANDRESA HEEMANN; DANUELLO, AMANDA; PIVATTO, MARCOS; CENTURIAO, FERNANDA; ANTONIO, CAMILA BOQUE; KUZE RATES, STELA MARIS; BOLZANI, VANDERLAN DA SILVA. Pyridinic analog of the natural product (-)-spectaline as potential adjuvant for the treatment of central nervous system disorders. Bioorganic & Medicinal Chemistry Letters, v. 25, n. 10, p. 2247-2250, MAY 15 2015. Web of Science Citations: 1.
SATAKE, KAZUHIRO; TSUKAMOTO, MEGUMI; MITANI, YUJI; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; EFFERTH, THOMAS; NAKAGAWA, HIROSHI. Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens. BIO-MEDICAL MATERIALS AND ENGINEERING, v. 25, n. 3, p. 249-256, 2015. Web of Science Citations: 2.
CHAPLA, VANESSA MARA; ZERAIK, MARIA LUIZA; LEPTOKARYDIS, IOANIS HCRISTOS; SILVA, GERALDO HUMBERTO; BOLZANI, VANDERLAN SILVA; YOUNG, MARIA CLAUDIA M.; PFENNING, LUDWIG HEINRICH; ARAUJO, ANGELA REGINA. Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca. Molecules, v. 19, n. 11, p. 19243-19252, NOV 2014. Web of Science Citations: 16.
PIVATTO, MARCOS; BACCINI, LUCIENE R.; SHARMA, ABHINAY; NAKABASHI, MYNA; DANUELLO, AMANDA; VIEGAS JUNIOR, CLAUDIO; GARCIA, CELIA R. S.; BOLZANI, VANDERLAN S. Antimalarial Activity of Piperidine Alkaloids from Senna spectabilis and Semisynthetic Derivatives. Journal of the Brazilian Chemical Society, v. 25, n. 10, p. 1900+, OCT 2014. Web of Science Citations: 7.
GUBIANI, JULIANA R.; ZERAIK, MARIA L.; OLIVEIRA, CAMILA M.; XIMENES, VALDECIR F.; NOGUEIRA, CLAUDIO R.; FONSECA, LUIZ M.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. Biologically Active Eremophilane-Type Sesquiterpenes from Camarops sp., an Endophytic Fungus Isolated from Alibertia macrophylla. Journal of Natural Products, v. 77, n. 3, p. 668-672, MAR 2014. Web of Science Citations: 11.
TAJIMA, YASUHIRO; NAKAGAWA, HIROSHI; TAMURA, AI; KADIOGLU, ONAT; SATAKE, KAZUHIRO; MITANI, YUJI; MURASE, HAYATO; REGASINI, LUIS OCTAVIO; BOLZANI, VANDERLAN DA SILVA; ISHIKAWA, TOSHIHISA; FRICKER, GERT; EFFERTH, THOMAS. Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, v. 21, n. 3, p. 323-332, FEB 15 2014. Web of Science Citations: 22.
ORLANDI SARDI, JANAINA DE CASSIA; PITANGUI, NAYLA DE SOUZA; RODRIGUEZ-ARELLANES, GABRIELA; LUCIA TAYLOR, MARIA; FUSCO-ALMEIDA, ANA MARIA; SOARES MENDES-GIANNINI, MARIA JOSE. Highlights in pathogenic fungal biofilms. REVISTA IBEROAMERICANA DE MICOLOGIA, v. 31, n. 1, p. 22-29, JAN 31 2014. Web of Science Citations: 42.
PILON, ALAN CESAR; CARNEIRO, R. L.; CARNEVALE NETO, F.; BOLZANI, VANDERLAN DA S.; CASTRO-GAMBOA, I. Interval Multivariate Curve Resolution in the Dereplication of HPLC-DAD Data from Jatropha gossypifolia. Phytochemical Analysis, v. 24, n. 4, p. 401-406, JUL-AUG 2013. Web of Science Citations: 16.
PRIETO, ALINE M.; DOS SANTOS, ANDRE G.; OLIVEIRA, ANA PAULA S.; CAVALHEIRO, ALBERTO J.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; VARANDA, ELIANA AP.; SOARES, CHRISTIANE P. Assessment of the chemopreventive effect of casearin B, a clerodane diterpene extracted from Casearia sylvestris (Salicaceae). Food and Chemical Toxicology, v. 53, p. 153-159, MAR 2013. Web of Science Citations: 14.
VIEGAS JUNIOR, CLAUDIO; PIVATTO, MARCOS; DE REZENDE, AMANDA; HAMERSKI, LIDILHONE; SIQUEIRA SILVA, DULCE HELENA; DA SILVA BOLZANI, VANDERLAN. (-)-7-Hydroxycassine: a New 2,6-Dialkylpiperidin-3-ol Alkaloid and other Constituents Isolated from Flowers and Fruits of Senna spectabilis (Fabaceae). Journal of the Brazilian Chemical Society, v. 24, n. 2, p. 230-235, FEB 2013. Web of Science Citations: 2.
PRIETO, A. M.; SANTOS, A. G.; CSIPAK, A. R.; CALIRI, C. M.; SILVA, I. C.; ARBEX, M. A.; SILVA, F. S.; MARCHI, M. R. R.; CAVALHEIRO, A. J.; SILVA, D. H. S.; BOLZANI, V. S.; SOARES, C. P. Chemopreventive activity of compounds extracted from Casearia sylvestris (Salicaceae) Sw against DNA damage induced by particulate matter emitted by sugarcane burning near Araraquara, Brazil. Toxicology and Applied Pharmacology, v. 265, n. 3, p. 368-372, DEC 15 2012. Web of Science Citations: 5.
PAVARINI, DANIEL P.; DA SILVA, DENISE B.; CAROLLO, CARLOS A.; PORTELLA, AMANDA P. F.; LATANSIO-AIDAR, SABRINA R.; CAVALIN, PEDRO O.; OLIVEIRA, VIVIANE C.; ROSADO, BRUNO H. P.; AIDAR, MARCOS P. M.; BOLZANI, VANDERLAN S.; LOPES, NORBERTO P.; JOLY, CARLOS A. Application of MALDI-MS analysis of Rainforest chemodiversity: a keystone for biodiversity conservation and sustainable use. Journal of Mass Spectrometry, v. 47, n. 11, p. 1482-1485, NOV 2012. Web of Science Citations: 7.
FLAUSINO, JR., O. A.; DUFAU, L.; REGASINI, L. O.; PETRONIO, M. S.; SILVA, D. H. S.; ROSE, T.; BOLZANI, V. S.; REBOUD-RAVAUX, M. Alkyl Hydroxybenzoic Acid Derivatives that Inhibit HIV-1 Protease Dimerization. Current Medicinal Chemistry, v. 19, n. 26, p. 4534-4540, SEP 2012. Web of Science Citations: 9.
ALVES, RENATA TOME; REGASINI, LUIS OCTAVIO; FUNARI, CRISTIANO SOLEO; MARX YOUNG, MARIA CLAUDIA; RIMOLDI, ALINE; BOLZANI, VANDERLAN DA SILVA; SIQUEIRA SILVA, DULCE HELENA; DE ALBUQUERQUE, SERGIO; DA ROSA, JOAO ARISTEU. Trypanocidal activity of Brazilian plants against epimastigote forms from Y and Bolivia strains of Trypanosoma cruzi. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 22, n. 3, p. 528-533, MAY-JUN 2012. Web of Science Citations: 8.
FRANCISCO, WELINGTON; PIVATTO, MARCOS; DANUELLO, AMANDA; REGASINI, LUIS O.; BACCINI, LUCIENE R.; YOUNG, MARIA C. M.; LOPES, NORBERTO P.; LOPES, JOAO L. C.; BOLZANI, VANDERLAN S. Pyridine Alkaloids from Senna multijuga As Acetylcholinesterase Inhibitors. Journal of Natural Products, v. 75, n. 3, p. 408-413, MAR 2012. Web of Science Citations: 13.
DANUELLO, AMANDA; ROMEIRO, NELILMA C.; GIESEL, GUILHERME M.; PIVATTO, MARCOS; VIEGAS, JR., CLAUDIO; VERLI, HUGO; BARREIRO, ELIEZER J.; FRAGA, CARLOS A. M.; CASTRO, NEWTON G.; BOLZANI, VANDERLAN S. Molecular Docking and Molecular Dynamic Studies of Semi-Synthetic Piperidine Alkaloids as Acetylcholinesterase Inhibitors. Journal of the Brazilian Chemical Society, v. 23, n. 1, p. 163-U505, JAN 2012. Web of Science Citations: 4.
BOLZANI, VANDERLAN DA SILVA; VALLI, MARILIA; PIVATTO, MARCOS; VIEGAS, JR., CLAUDIO. Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry. Pure and Applied Chemistry, v. 84, n. 9, p. 1837-1846, 2012. Web of Science Citations: 24.
MASCIA LOPES, FLAVIA CRISTINE; ROCHA, ANA; PIRRACO, ANA; REGASINI, LUIS O.; SIQUEIRA, JANAINA R.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; CARLOS, IRACILDA Z.; SOARES, RAQUEL. Alchornea glandulosa Ethyl Acetate Fraction Exhibits Antiangiogenic Activity: Preliminary Findings from In Vitro Assays Using Human Umbilical Vein Endothelial Cells. JOURNAL OF MEDICINAL FOOD, v. 14, n. 10, p. 1244-1253, OCT 2011. Web of Science Citations: 5.
VALLI, M.; DANUELLO, A.; PIVATTO, M.; SALDANA, J. C.; HEINZEN, H.; DOMINGUEZ, L.; CAMPOS, V. P.; MARQUI, S. R.; YOUNG, M. C. M.; VIEGAS, JR., C.; SILVA, D. H. S.; BOLZANI, V. S. Anticholinesterasic, Nematostatic and Anthelmintic Activities of Pyridinic and Pyrazinic Compounds. Current Medicinal Chemistry, v. 18, n. 22, p. 3423-3430, AUG 2011. Web of Science Citations: 7.
OLIVEIRA, CAMILA M.; REGASINI, LUIS O.; SILVA, GERALDO H.; PFENNING, LUDWIG H.; YOUNG, MARIA C. M.; BERLINCK, ROBERTO G. S.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. Dihydroisocoumarins produced by Xylaria sp and Penicillium sp., endophytic fungi associated with Piper aduncum and Alibertia macrophylla. PHYTOCHEMISTRY LETTERS, v. 4, n. 2, p. 93-96, JUN 15 2011. Web of Science Citations: 25.
DE OLIVEIRA, CAMILA MARTINS; SILVA, GERALDO HUMBERTO; REGASINI, LUIS OCTAVIO; FLAUSINO, JR., OTAVIO; NOELI LOPEZ, SILVIA; ABISSI, BARBARA MARCONDES; DE SOUZA BERLINCK, ROBERTO GOMES; SETTE, LARA DURAES; BONUGLI-SANTOS, RAFAELLA COSTA; RODRIGUES, ANDRE; BOLZANI, VANDERLAN DA SILVA; ARAUJO, ANGELA REGINA. Xylarenones C-E from an Endophytic Fungus Isolated from Alibertia macrophylla. Journal of Natural Products, v. 74, n. 6, p. 1353-1357, JUN 2011. Web of Science Citations: 9.
BATISTA, JR., JOAO M.; BATISTA, ANDREA N. L.; RINALDO, DANIEL; VILEGAS, WAGNER; AMBROSIO, DANIELA L.; CICARELLI, REGINA M. B.; BOLZANI, VANDERLAN S.; KATO, MASSUO J.; NAFIE, LAURENCE A.; LOPEZ, SILVIA N.; FURLAN, MAYSA. Absolute Configuration and Selective Trypanocidal Activity of Gaudichaudianic Acid Enantiomers. Journal of Natural Products, v. 74, n. 5, p. 1154-1160, MAY 2011. Web of Science Citations: 30.
BATISTA, JR., JOAO M.; BATISTA, ANDREA N. L.; MOTA, JONAS S.; CASS, QUEZIA B.; KATO, MASSUO J.; BOLZANI, VANDERLAN S.; FREEDMAN, TERESA B.; LOPEZ, SILVIA N.; FURLAN, MAYSA; NAFIE, LAURENCE A. Structure Elucidation and Absolute Stereochemistry of Isomeric Monoterpene Chromane Esters. Journal of Organic Chemistry, v. 76, n. 8, p. 2603-2612, APR 15 2011. Web of Science Citations: 29.
VIEIRA-JUNIOR, GERARDO M.; DUTRA, LUIZ A.; FERREIRA, PAULO M. P.; DE MORAES, MANOEL O.; LOTUFO, LETICIA V. COSTA; PESSOA, CLAUDIA DO O.; TORRES, ROSELI BUZANELLI; BORALLE, NIVALDO; BOLZANI, VANDERLAN DA S.; CAVALHEIRO, ALBERTO J. Cytotoxic Clerodane Diterpenes from Casearia rupestris. Journal of Natural Products, v. 74, n. 4, p. 776-781, APR 2011. Web of Science Citations: 27.
CARDOSO, CARMEN L.; CASTRO-GAMBOA, IAN; BERGAMINI, GIOVANA M.; CAVALHEIRO, ALBERTO J.; SILVA, DULCE H. S.; LOPES, MARCIA N.; ARAUJO, ANGELA R.; FURLAN, MAYSA; VERLI, HUGO; BOLZANI, VANDERLAN DA S. An Unprecedented Neolignan Skeleton from Chimarrhis turbinata. Journal of Natural Products, v. 74, n. 3, p. 487-491, MAR 2011. Web of Science Citations: 8.
CARDOSO-LOPES, ELAINE MONTEIRO; MAIER, JAMES ANDREAS; DA SILVA, MARCELO ROGERIO; RAGASINI, LUIS OCTAVIO; SIMOTE, SIMONE YASUE; LOPES, NORBERTO PEPORINE; PIRANI, JOSE RUBENS; BOLZANI, VANDERLAN DA SILVA; MARX YOUNG, MARIA CLAUDIA. Alkaloids from Stems of Esenbeckia leiocarpa Engl. (Rutaceae) as Potential Treatment for Alzheimer Disease. Molecules, v. 15, n. 12, p. 9205-9213, DEC 2010. Web of Science Citations: 30.
BATISTA, JR., JOAO MARCOS; BATISTA, ANDREA N. L.; RINALDO, DANIEL; VILEGAS, WAGNER; CASS, QUEZIA B.; BOLZANI, VANDERLAN S.; KATO, MASSUO J.; LOPEZ, SILVIA N.; FURLAN, MAYSA; NAFIE, LAURENCE A. Absolute configuration reassignment of two chromanes from Peperomia obtusifolia (Piperaceae) using VCD and DFT calculations. TETRAHEDRON-ASYMMETRY, v. 21, n. 19, p. 2402-2407, OCT 7 2010. Web of Science Citations: 43.
SILVA, GERALDO H.; DE OLIVEIRA, CAMILA M.; TELES, HELDER L.; PAULETTI, PATRICIA M.; CASTRO-GAMBOA, IAN; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; YOUNG, MARIA C. M.; COSTA-NETO, CLAUDIO M.; PFENNING, LUDWIG H.; BERLINCK, ROBERTO G. S.; ARAUJO, ANGELA R. Sesquiterpenes from Xylaria sp., an endophytic fungus associated with Piper aduncum (Piperaceae). PHYTOCHEMISTRY LETTERS, v. 3, n. 3, p. 164-167, SEP 20 2010. Web of Science Citations: 30.
SERRANO, MARIA A. R.; PIVATTO, MARCOS; FRANCISCO, WELINGTON; DANUELLO, AMANDA; REGASINI, LUIS O.; LOPES, ELAINE M. C.; LOPES, MARCIA N.; YOUNG, MARIA C. M.; BOLZANI, VANDERLAN S. Acetylcholinesterase Inhibitory Pyridine Alkaloids of the Leaves of Senna multijuga. Journal of Natural Products, v. 73, n. 3, SI, p. 482-484, MAR 2010. Web of Science Citations: 9.
DE OLIVEIRA, ALINE M.; DOS SANTOS, ANDRE G.; DOS SANTOS, RAQUEL A.; CSIPAK, ANGELICA R.; OLIVATO, CAMILA; DA SILVA, ISABEL C.; DE FREITAS, MAURA B.; BASSI, CARMEN L.; CAVALHEIRO, ALBERTO J.; BOLZANI, VANDERLAN S.; SILVA, DULCE H. S.; SAKAMOTO-HOJO, ELZA T.; TAKAHASHI, CATARINA S.; SOARES, CHRISTIANE P. Ethanolic extract of Casearia sylvestris and its clerodane diterpen (caseargrewiin F) protect against DNA damage at low concentrations and cause DNA damage at high concentrations in mice's blood cells. MUTAGENESIS, v. 24, n. 6, p. 501-506, NOV 2009. Web of Science Citations: 11.
OLIVEIRA, CAMILA M.; SILVA, GERALDO H.; REGASINI, LUIS O.; ZANARDI, LISINEIA M.; EVANGELISTA, ALANA H.; YOUNG, MARIA C. M.; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R. Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae). ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, v. 64, n. 11-12, p. 824-830, NOV-DEC 2009. Web of Science Citations: 20.
LOPES, FLAVIA C. M.; ROCHA, ANA; PIRRACO, ANA; REGASINI, LUIS O.; SILVA, DULCE H. S.; BOLZANI, VANDERLAN S.; AZEVEDO, ISABEL; CARLOS, IRACILDA Z.; SOARES, RAQUEL. Anti-angiogenic effects of pterogynidine alkaloid isolated from Alchornea glandulosa. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, v. 9, MAY 22 2009. Web of Science Citations: 15.
REGASINI, LUIS OCTAVIO; CASTRO-GAMBOA, IAN; SIQUEIRA SILVA, DULCE HELENA; FURLAN, MAYSA; BARREIRO, ELIEZER JESUS; PINHEIRO FERREIRA, PAULO MICHEL; PESSOA, CLAUDIA; COSTA LOTUFO, LETICIA VERAS; DE MORAES, MANOEL ODORICO; MARX YOUNG, MARIA CLAUDIA; BOLZANI, VANDERLAN DA SILVA. Cytotoxic Guanidine Alkaloids from Pterogyne nitens. Journal of Natural Products, v. 72, n. 3, SI, p. 473-476, MAR 2009. Web of Science Citations: 32.
ELAINE MONTEIRO CARDOSO-LOPES; DAISY MARIA BENTES DE PAULA; FAUSTO ERRITTO BARBO; AMANDA DE SOUZA; CECÍLIA TERUMI TERADAIRA BLATT; LUCE MARIA BRANDÃO TORRES; MARIA CLÁUDIA MARX YOUNG. Chemical composition, acetylcholinesterase inhibitory and antifungal activities of Pera glabrata (Schott) Baill. (Euphorbiaceae). BRAZILIAN JOURNAL OF BOTANY, v. 32, n. 4, p. 819-825, Dez. 2009.
CARDOSO-LOPES, ELAINE MONTEIRO; CARREIRA, ROSANA CRISTINA; AGRIPINO, DEBORA GOMES; BRANDAO TORRES, LUCE MARIA; CORDEIRO, INES; BOLZANI, VANDERLAN DA SILVA; DE CAMPOS DIETRICH, SONIA MACHADO; MARX YOUNG, MARIA CLAUDIA. Screening for antifungal, DNA-damaging and anticholinesterasic activities of Brazilian plants from the Atlantic Rainforest - Ilha do Cardoso State Park. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 18, n. S, p. 655-660, DEC 2008. Web of Science Citations: 14.
GOBBO-NETO, LEONARDO; GATES, PAUL J.; LOPES, NORBERTO P. Negative ion `chip-based' nanospray tandem mass spectrometry for the analysis of flavonoids in glandular trichomes of Lychnophora ericoides Mart. (Asteraceae). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 22, n. 23, p. 3802-3808, DEC 2008. Web of Science Citations: 20.
SARA REGINA DE MARQUI; RENATA BRIONÍZIO LEMOS; LUCIANA ÁVILA SANTOS; IAN CASTRO-GAMBOA; ALBERTO JOSÉ CAVALHEIRO; VANDERLAN DA SILVA BOLZANI; DULCE HELENA SIQUEIRA SILVA; LILIANA SCORZONI; ANA MARIA FUSCO-ALMEIDA; MARIA JOSÉ SOARES MENDES-GIANNINI; MARIA CLAUDIA MARX YOUNG; LUCE MARIA BRANDÃO TORRES. Saponinas antifúngicas de Swartzia langsdorffii. Química Nova, v. 31, n. 4, p. 828-831, 2008.
CARBONEZI, CARLOS ALBERTO; HAMERSKI, LIDILHONE; GUNATILAKA, A. LESLIE; CAVALHEIRO, ALBERTO; CASTRO-GAMBOA, IAN; SILVA, DULCE HELENA SIQUEIRA; FURLAN, MAYSA; YOUNG, MARIA CLAUDIA MARX; LOPES, MARCIA NASSER; BOLZANI, VANDERLAN DA SILVA. Bioactive flavone dimers from Ouratea multiflora (Ochnaceae). REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 17, n. 3, p. 319-324, jul.-set. 2007.
FLAUSINO JÚNIOR, OTAVIO; SANTOS, LUCIANA DE ÁVILA; VERLI, HUGO; PEREIRA, ANA MARIA; BOLZANI, VANDERLAN DA SILVA; NUNES-DE-SOUZA, RICARDO LUIZ. Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu. Journal of Natural Products, v. 70, n. 1, p. 48-53, Jan. 2007.
FLAUSINO‚ JR‚ O.A.; PEREIRA‚ A.M.; BOLZANI‚ V.S.; NUNES-DE-SOUZA‚ R.L. Effects of erythrinian alkaloids isolated from Erythrina mulungu (Papilionaceae) in mice submitted to animal models of anxiety. BIOLOGICAL & PHARMACEUTICAL BULLETIN, v. 30, n. 2, p. 375-378, 2007.
TELES, HELDER LOPES; SORDI, RENATA; SILVA, GERALDO HUMBERTO; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN DA SILVA; PFENNING, LUDWIG HEINRICH; ABREU, LUCAS MAGALHÃES DE; COSTA-NETO, CLAUDIO MIGUEL; YOUNG, MARIA CLAUDIA MARX; ARAÚJO, ÂNGELA REGINA. Aromatic compounds produced by Periconia atropurpurea, an endophytic fungus associated with Xylopia aromatica. Phytochemistry, v. 67, n. 24, p. 2686-2690, Dec. 2006.
SILVA, GERALDO HUMBERTO; TELES, HELDER LOPES; ZANARDI, LISINÉIA MARIA; YOUNG, MARIA CLAUDIA MARX; EBERLIN, MARCOS NOGUEIRA; HADAD, RENATO; PFENNING, LUDWIG H.; COSTA-NETO, CLAUDIO MIGUEL; CASTRO-GAMBOA, IAN; BOLZANI, VANDERLAN DA SILVA; ARAÚJO, ÂNGELA REGINA. Cadinane sesquiterpenoids of Phomopsis cassiae, an endophytic fungus associated with Cassia spectabilis (Leguminosae). Phytochemistry, v. 67, n. 17, p. 1964-1969, Sept. 2006.
CARDOSO, CARMEN LUCIA; BOLZANI, VANDERLAN DA SILVA; SILVA, DULCE HELENA SIQUEIRA; ISHII, HIDEKI; BEROVA, NINA; NAKANISHI, KOJI. The absolute configuration of 1-(3 ',4 '-dihydroxycinnamoyl)cyclopentane-2,3-diol from the Amazonian tree Chimarrhis turbinata. Journal of Natural Products, v. 69, n. 7, p. 1046-1050, July. 2006.
PAULETTI, PATRÍCIA M.; TELES, HELDER L.; SILVA, DULCE H. S.; ARAÚJO, ÂNGELA R.; BOLZANI, VANDERLAN S. The Styracaceae. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 16, n. 4, p. 576-590, Out.-Dec. 2006.
CAFÊU, MARIANA C.; SILVA, GERALDO H.; TELES, HELDER L.; BOLZANI, VANDERLAN DA S.; ARAÚJO, ÂNGELA R.; YOUNG, MARIA CLÁUDIA M.; PFENNING, LUDWIG H. Substâncias antifúngicas de Xylaria sp., um fungo endofítico isolado de Palicourea marcgravii (Rubiaceae). Química Nova, v. 28, n. 6, p. 991-995, nov.-dez. 2005.
CARMEM L. CARDOSO; DULCE H. S. SILVA; IAN CASTRO-GAMBOA; VANDERLAN DA S. BOLZANI. New biflavonoid and other flavonoids from the leaves of Chimarrhis turbinata and their antioxidant activities. Journal of the Brazilian Chemical Society, v. 16, n. 6b, p. 1353-1359, Nov.- Dec. 2005.
GERALDO H. SILVA; HELDER L. TELES; HENRIQUE C. TREVISAN; VANDERLAN DA S. BOLZANI; MARIA C. M. YOUNG; LUDWIG H. PFENNING; MARCOS N. EBERLIN; RENATO HADDAD; CLAUDIO M. COSTA-NETO; ÂNGELA R. ARAÚJO. New bioactive metabolites produced by Phomopsis cassiae, an endophytic fungus in Cassia spectabilis. Journal of the Brazilian Chemical Society, v. 16, n. 6b, p. 1463-1466, Nov.- Dec. 2005.
MARCOS PIVATTO; ANTÔNIO E. M. CROTTI; NORBERTO P. LOPES; IAN CASTRO-GAMBOA; AMANDA DE REZENDE; CLÁUDIO VIEGAS JR.; MARIA CLAUDIA M. YOUNG; MAYSA FURLAN; VANDERLAN S. BOLZANI. Electrospray ionization mass spectrometry screening of piperidine alkaloids from Senna spectabilis (Fabaceae) extracts: fast identification of new constituents and co-metabolites. Journal of the Brazilian Chemical Society, v. 16, n. 6b, p. 1431-1438, Nov. 2005.
LOPES, MARCIA N.; OLIVEIRA, ANDRÉ C. DE; YOUNG, MARIA CLÁUDIA M.; BOLZANI, VANDERLAN DA S. Flavonoids from Chiococca braquiata (Rubiaceae). Journal of the Brazilian Chemical Society, v. 15, n. 4, p. 468-471, July.-Aug. 2004.
CARBONEZI, CARLOS ALBERTO; LOPES, MÁRCIA NASSER; SILVA, DULCE HELENA SIQUEIRA; ARAÚJO, ÂNGELA REGINA; BOLZANI, VANDERLAN DA SILVA; YOUNG, MARIA CLAUDIA MARX; SILVA, MARCELO ROGÉRIO DA. Derivado cinamoílico com atividade no reparo de DNA e outras substâncias de Cinnamomum australe (Lauraceae). Química Nova, v. 27, n. 2, p. 196-198, mar.-abr. 2004.

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EXTRATOS, FRAÇÕES ATIVAS E/OU COMPOSTOS ISOLADOS DE CASEARIA SYLVESTRIS, FORMULAÇÕES FARMACÊUTICAS E SEUS USOS PI0900645-1 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Universidade de São Paulo (USP) ; Universidade Estadual Paulista (UNESP) . André Gonzaga dos Santos; Jayme Antônio Aboin Sertié; Ricardo Gomide Woisky do Rio; Alberto José Cavalheiro; Aristeu Gomes Tininis; Vanderlan da Silva Bolzani; Marcelo Rodrigues - March 2009, 11