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Study of Chrysobalanaceae species with cytotoxic activities: Metabolomic analysis for the understanding of sinergistic associations and their micromolecular complexity

Grant number: 10/07564-9
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2010
Effective date (End): August 31, 2014
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Ian Castro-Gamboa
Grantee:Fausto Carnevale Neto
Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Associated research grant:03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II, AP.BTA.TEM
Associated scholarship(s):12/20672-0 - Metabolomics studies for the determination of cytotoxic activity of Chrysobalanaceae plant species From the Brazilian Cerrado, BE.EP.DR


The need for new and innovative analytical methods that may shed information towards complex natural matrixes composition is a keystone on bioprospecting programs. Dereplication methodologies associated to state of the art spectroscopic techniques as well as in vitro bioassays, have been successful in the selection of biologically active extracts. Our research group "NuBBE" (Nuclei of Bioassays, Biosynthesis and Ecophysiology of Natural Products) has incorporated experimental strategies and chromatographic methods to select, from our bank of extract, promising candidates for further studies. Recently the use of high performance liquid chromatography (HPLC) hyphenated with high resolution mass spectrometry (HRMS) allowed us to analyze plant and endophytic fungi extracts speeding up the selection of biologically active fractions as well as assisting on chemical composition studies of the known bioactive chemotypes and selecting those with novel molecular characteristics for further separation and purification. Innovative spectroscopic techniques using Nuclear Magnetic Resonance (NMR) recently applied on the study of dynamic complex matrixes are being integrated with HPLC methods mainly due to their robustness, low sample amounts and spectroscopic versatilities. The goal of this proposal is to increase the understanding of molecular relationships on dynamic natural matrixes and thus, establishing a rational approach for the study of bioactive natural products. To fulfill this task plant species from our bank of extracts, belonging to Chrysobalanaceae, having little phytochemical studies but promising citotoxicity, were selected to apply these new analytical methods.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NETO, FAUSTO CARNEVALE; ANDREO, MARCIO ADRIANO; RAFTERY, DANIEL; CALLEGARI LOPES, JOAO LUIS; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; DE NORONHA SALES MAIA, BEATRIZ HELENA LAMEIRO; COSTA, EMMANOEL VILACA; VESSECCHI, RICARDO. Characterization of aporphine alkaloids by electrospray ionization tandem mass spectrometry and density functional theory calculations. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 3, SI, . (10/07564-9, 14/23604-1, 03/02176-7, 14/12343-2, 09/08281-3, 14/50265-3)
PILON, ALAN CESAR; GU, HAIWEI; RAFTERY, DANIEL; BOLZANI, VANDERLAN DA SILVA; LOPES, NORBERTO PEPORINE; CASTRO-GAMBOA, IAN; CARNEVALE NETO, FAUSTO. Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates. Analytical Chemistry, v. 91, n. 16, p. 10413-10423, . (16/13292-8, 10/17935-4, 03/02176-7, 14/12343-2, 10/07564-9, 14/50265-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
CARNEVALE NETO, Fausto. Estudo de espécies de Chrysobalanaceae com ação citotóxica: análise metabolômica visando ao entendimento de associações sinérgicas e da complexidade micromolecular. 2014. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Química. Araraquara Araraquara.

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