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Studies on ovarian and uterine physiology and improvement of Assisted Reproduction Technologies to increase reproductive efficiency in cattle


Experiments will be performed to better understand physiological aspects related to ovulation and maintenance of pregnancy in bovine females submitted to artificial insemination (AI) or embryo transfer (ET). In addition, studies will evaluate strategies to increase efficiency and/or simplify the use of fixed-time artificial insemination (FTAI) or embryo production protocols. Twenty-six experiments will be performed within six main themes, three of them about reproductive physiology (1 - Mechanisms involved in the maintenance of pregnancy; 2 - Ovarian, uterine and endocrine changes in response to different treatments or hormonal concentrations; 3 - Ovarian dynamics and embryo quality in FTAI protocols) and other three focused on reproductive biotechnologies (4 - Reproductive efficiency in Nelore cows and heifers submitted to FTAI protocols; 5 - Reproductive efficiency in dairy cows submitted to FTAI protocols; 6 - In vivo embryo production in superovulated cows inseminated with refrigerated sexed spermatozoa), in both beef cattle and dairy cattle. In these experiments, approximately 20,000 animals will be used. We will be performing sperm evaluations of the sires used, ovarian and transrectal uterine ultrasound examinations, blood sampling for hormone assays, and uterine flushings (when appropriate) to study ovarian and uterine dynamics and functions, embryo quality and fertility. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BASAVARAJA, RAGHAVENDRA; DRUM, JESSICA N.; SAPULENI, JACKSON; BIBI, LONICE; FRIEDLANDER, GILGI; KUMAR, SAI; SARTORI, ROBERTO; MEIDAN, RINA. Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro. BMC Genomics, v. 22, n. 1, . (18/03798-7)
ALVES, RODRIGO L. O. R.; SILVA, MATEUS A.; CONSENTINI, CARLOS E. C.; SILVA, LUCAS O. E.; FOLCHINI, NATALIA P.; OLIVA, ABRAHAM L.; PRATA, ALEXANDRE B.; GONCALVES, JOSE RENATO S.; WILTBANK, MILO C.; SARTORI, ROBERTO. Hormonal combinations aiming to improve reproductive outcomes of Bos indicus cows submitted to estradiol/progesterone-based timed AI protocols. Theriogenology, v. 169, p. 89-99, . (18/03798-7, 18/14723-8)
CARDOSO CONSENTINI, CARLOS EDUARDO; WILTBANK, MILO CHARLES; SARTORI, ROBERTO. Factors That Optimize Reproductive Efficiency in Dairy Herds with an Emphasis on Timed Artificial Insemination Programs. ANIMALS, v. 11, n. 2, . (17/15904-3, 18/03798-7)
MOTTA, JESSICA C. L.; MADUREIRA, GUILHERME; SILVA, LUCAS O.; ALVES, RODRIGO L. O. R.; SILVESTRI, MAYARA; DRUM, JESSICA N.; CONSENTINI, CARLOS E. C.; PRATA, ALEXANDRE B.; POHLER, KY G.; WILTBANK, MILO C.; et al. Interactions of circulating estradiol and progesterone on changes in endometrial area and pituitary responsiveness to GnRH. BIOLOGY OF REPRODUCTION, v. 103, n. 3, p. 643-653, . (18/03798-7, 17/16701-9, 18/09266-7)
PRATA, ALEXANDRE B.; MADUREIRA, GUILHERME; ROBL, ADELINO J.; RIBEIRO, HEULLER S.; SAGAE, MILTON; ELIAS, V, MANOEL C.; PIMENTA, CESAR; BARRIOS, JHONNY; HARTMMAN, DIEGO; SCHNEIDER, ALTHUIR A.; et al. Progesterone-based timed AI protocols for Bos indicus cattle III: Comparison of protocol lengths. Theriogenology, v. 152, p. 29-35, . (18/03798-7)

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