Manufacturing of dense bovine hydroxyapatite ceramics with added TiO2 nanoparticles: innovation for sustainability

• Grant number: 18/23639-0
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2019
• End date: May 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Ana Flávia Sanches Borges
• Grantee: Ana Flávia Sanches Borges
• Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Associated researchers: Carlos Alberto Fortulan ; Diana Gabriela Soares dos Passos ; Paulo Noronha Lisboa Filho

Abstract

The production of a bovine dense hydroxyapatite ceramic (HA) could be a promising polycrystalline biomaterial, to join the chemical advantages of HA and the need to produce as the minimum possible solid waste from bovine bones. The present research project is the synthesis of ideas from a group of interdisciplinary researchers and students from Bauru School of Dentistry (FOB/USP), Department of Physics of the School of Sciences (UNESP/Bauru), School of Engineering of São Carlos (EESC/USP), and The University of Mississippi Medical Center, Jackson, MS, USA. The purpose of this study is to evaluate the role of different percentages of TiO2 nanoparticles (0%, 5 or 8%) in the HA microstructure, by mechanical analyses: (1) flexural strength and reliability; (2) fracture toughness by hardness; (3) fracture toughness by surface crack in flexure (SCF); as well as by surface analyses - (4) odontoblasts human cells viability and mineralized matrix deposition; (5) chemical attraction to different locations on the materials' surface by atomic force microscopy (AFM). The results from these tests will provide a mechanical and biological overview of this newest experimental material that it is expected to be used for dental applications. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PIRES, LUARA A.; DE MEIRA, CAMILA R.; TOKUHARA, CINTIA K.; DE OLIVEIRA, FLAVIA A.; DAINEZI, VANESSA B.; GRAEFF, MARCIA S. ZARDIN; FORTULAN, CARLOS A.; DE OLIVEIRA, RODRIGO C.; PUPPIN-RONTANI, REGINA M.; BORGES, ANA FLAVIA S.. Wettability and pre-osteoblastic behavior evaluations of a dense bovine hydroxyapatite ceramics. JOURNAL OF ORAL SCIENCE, v. 62, n. 3, p. 259-264, JUL 2020. (11/18061-0, 12/07283-5, 12/06738-9, 18/23639-0)

FERRAIRO, BRUNNA MOTA; MOSQUIM, VICTOR; DE AZEVEDO-SILVA, LUCAS JOSE; PIRES, LUARA ALINE; PADOVINI, DAVID SANTOS SOUZA; MAGDALENA, AROLDO GERALDO; FORTULAN, CARLOS ALBERTO; LISBOA-FILHO, PAULO NORONHA; RUBO, JOSE HENRIQUE; BORGES, ANA FLAVIA SANCHES. Production of bovine hydroxyapatite nanoparticles as a promising biomaterial via mechanochemical and sonochemical methods. Materials Chemistry and Physics, v. 295, p. 7-pg., 2023-02-01. (18/23639-0)

MONTEIRO, RAPHAELLE SANTOS; FERRAIRO, BRUNNA MOTA; DE AZEVEDO-SILVA, LUCAS JOSE; MINIM, PEDRO RODRIGUES; RUBO, JOSE HENRIQUE; FURUSE, ADILSON YOSHIO; SILIKAS, NIKOLAOS; BORGES, ANA FLAVIA SANCHES. Glass ceramics behave like selectively etched enamel on interfaces produced with self-adhesive/self-curing resin cement. INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, v. 124, p. 7-pg., 2023-05-18. (18/23639-0)

PIRES, LUARA ALINE; DE AZEVEDO SILVA, LUCAS JOSE; FERRAIRO, BRUNNA MOTA; ERBERELI, ROGERIO; PARREIRA LOVO, JOAO FIORE; GOMES, ORISSON PONCE; RUBO, JOSE HENRIQUE; LISBOA-FILHO, PAULO NORONHA; GRIGGS, JASON ALAN; FORTULAN, CARLOS ALBERTO; et al. Effects of ZnO/TiO2 nanoparticle and TiO2 nanotube additions to dense polycrystalline hydroxyapatite bioceramic from bovine bones. Dental Materials, v. 36, n. 2, p. E38-E46, FEB 2020. (13/07296-2, 18/23639-0)

FERNANDES, PAULO HENRIQUE MARTINS; BORDINI, ESTER ALVES FERREIRA; CASSIANO, FERNANDA BALESTRERO; DE AZEVEDO-SILVA, LUCAS JOSE; FERRAIRO, BRUNNA MOTA; LISBOA-FILHO, PAULO NORONHA; FORTULAN, CARLOS ALBERTO; DOS PASSOS, DIANA GABRIELA SOARES; BORGES, ANA FLAVIA SANCHES. TiO2 nanoparticles added to dense bovine hydroxyapatite bioceramics increase human osteoblast mineralization activity. Dental Materials, v. 38, n. 11, p. 9-pg., 2022-10-14. (18/23639-0, 13/07296-2, 16/15674-5)

SOUZA PADOVINI, DAVID SANTOS; DE AZEVEDO-SILVA, LUCAS JOSE; FERRAIRO, BRUNNA MOTA; PEREIRA, LETICIA FLORINDO; MINIM, PEDRO RODRIGUES; LIMA PONTES, FENELON MARTINHO; FORTULAN, CARLOS ALBERTO; SANCHES BORGES, ANA FLAVIA. Hydroxyapatite/ZrO₂@SiO₂ bioceramic composite: Producing a promising biomaterial from natural sources. MRS COMMUNICATIONS, v. 13, n. 4, p. 7-pg., 2023-07-27. (18/23639-0)

MINIM, P. R.; DE AZEVEDO-SILVA, L. J.; FERRAIRO, B. M.; PEREIRA, L. F.; GOULART, C. A.; MONTEIRO-SOUSA, R. S.; LISBOA, P. N.; FORTULAN, C. A.; SALOMA, R.; BORGES, A. F. S.; et al. The combined effects of binder addition and different sintering methods on the mechanical properties of bovine hydroxyapatite. JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, v. 144, p. 9-pg., 2023-06-27. (18/23639-0)