Thyroid hormones action on 3xTg-AD (APPswe, PS1m146v, tauP301L) Alzheimer's Disease mice model

• Grant number: 17/23169-1
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2019
• End date: April 30, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Gisele Giannocco
• Grantee: Gisele Giannocco
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
• Associated researchers: Cléber Pinto Camacho ; Rui Monteiro de Barros Maciel

Abstract

The prevalence of brain disorders affecting cognition (such as stroke and dementia) increases steadily in a linear fashion as age increases. Alzheimer's disease (AD) is the most frequent cause of dementia, increasing in prevalence from less than 1% below the age of 60 years to more than 40% above 85 years old. Worldwide, 35.6 million people have either Alzheimer's or dementia, according to the World Health Organization; it is expected to triple by 2050. The neuropathologic features of this disease are senile plaques and neurofibrillary tangles, which are present in memory structures and cerebral cortex. Several population-based studies have demonstrated an association between hypo-or hyperthyroidism and dementia in the last two decades. Patients with AD as well as other dementias had signs of mild brain hypothyroidism. This neurodegenerative disease represent a challenge for basic science and clinical medicine because of increasing prevalence, social cost, complex biochemistry and pathology, and lack of mechanism-based treatments. This study focuses on evaluation of possible mechanisms of thyroid hormones lack and administration in the management of neurological changes accompanied with AD on 3xTg-AD (APPswe, PS1m146v, tauP301L) Alzheimer's Disease mice and model and wild type animals. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GIANNOCCO, GISELE; LETRO KIZYS, MARINA MALTA; MACIEL, RUI MONTEIRO; DE SOUZA, JANAINA SENA. Thyroid hormone, gene expression, and Central Nervous System: Where we are. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 114, p. 10-pg., 2021-05-20. (17/23169-1, 18/22763-0, 17/07053-3)

OLIVEIRA, KELEN CARNEIRO; LAUREANO-MELO, ROBERTO; DA CONCEICAO, RODRIGO RODRIGUES; DE SOUZA, JANAINA SENA; DA SILVA CORTES, WELLINGTON; SATO, MONICA AKEMI; CHIAMOLERA, MARIA IZABEL; MACIEL, RUI MONTEIRO; GIANNOCCO, GISELE. Thyroxine replacement modifies changes in deiodinase and thyroid hormone transporter expression induced by subclinical hypothyroidism in rats. HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, v. 20, n. 1, p. 10-pg., 2020-09-29. (17/23169-1, 18/22763-0, 17/07053-3)

GIANNOCCO, GISELE; LETRO KIZYS, MARINA MALTA; MACIEL, RUI MONTEIRO; DE SOUZA, JANAINA SENA. Thyroid hormone, gene expression, and Central Nervous System: Where we are. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, v. 114, n. SI, p. 47-56, JUN 2021. (17/23169-1, 17/07053-3, 18/22763-0)

LAUREANO-MELO, ROBERTO; DOS-SANTOS, RAONI CONCEICAO; DA CONCEICAO, RODRIGO RODRIGUES; DE SOUZA, JANAINA SENA; ALMEIDA, CLAUDIO DA SILVA; REIS, LUIS CARLOS; MARINHO, BRUNO GUIMARAES; GIANNOCCO, GISELE; AHMED, RAGAB GABER; CORTES, WELLINGTON DA SILVA. Neonatal D-fenfluramine treatment promotes long-term behavioral changes in adult mice. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. N/A, p. 13-pg., 2022-06-29. (17/23169-1, 18/22763-0, 17/07053-3)

MAGLIONE, ANDREA, V; DO NASCIMENTO, BRUNA P. P.; RIBEIRO, MIRIAM O.; DE SOUZA, TALYTHA J. L.; DA SILVA, RENATA E. C.; SATO, MONICA A.; PENATTI, CARLOS A. A.; BRITTO, LUIZ R. G.; DE SOUZA, JANAINA S.; MACIEL, RUI M. B.; et al. Triiodothyronine Treatment reverses Depression-Like Behavior in a triple-transgenic animal model of Alzheimer's Disease. METABOLIC BRAIN DISEASE, v. 37, n. 8, p. 16-pg., 2022-08-11. (17/23169-1)

LAUREANO-MELO, ROBERTO; DOS-SANTOS, RAONI CONCEICAO; DA CONCEICAO, RODRIGO RODRIGUES; DE SOUZA, JANAINA SENA; LAU, RAPHAEL DA SILVA; SOUZA SILVA, SAMANTHA DA SILVA; MARINHO, BRUNO GUIMARAES; GIANNOCCO, GISELE; AHMED, R. G.; CORTES, WELLINGTON DA SILVA. Perinatal fluoxetine treatment promotes long-term behavioral changes in adult mice. METABOLIC BRAIN DISEASE, v. 35, n. 8, AUG 2020. (18/22763-0, 17/07053-3, 17/23169-1)