Use of anti-inflammatory agents associated with probiotic: a likely alternative to the use of antimicrobials as growth promoters: study in broiler

• Grant number: 18/19474-6
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2019
• End date: April 30, 2023
• Field of knowledge: Agronomical Sciences - Veterinary Medicine
• Principal Investigator: Silvana Lima Gorniak
• Grantee: Silvana Lima Gorniak
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: André Tadeu Gotardo ; Cristiane Soares da Silva Araújo ; Edimar Cristiano Pereira ; Isis Machado Hueza ; Newton Andréo Filho ; Terezinha Knöbl
• Associated scholarship(s): 19/17854-9 - Probiotic-associated anti-inflammatory use: a likely alternative to the use of antimicrobials as performance enhancers: study in broilers, BP.TT

Abstract

Antimicrobial resistance is probably the biggest problem to be faced by health authorities around the world today. Studies have shown that many species of resistant bacteria that are present in the agricultural environment can affect human health by complex pathways of environmental exposure. Thus, there is a clear relationship between the use of antimicrobial in animal production, particularly when used sub-therapeutically, as growth promoters (AGP) and the increased prevalence/incidence of resistant microorganisms. If, on the one hand, the ban of AGP will be beneficial to human health and animal health and welfare, on the other hand, it should be considered that banning antimicrobials in this case may have very serious implications for the economy, particularly in countries such as Brazil. In fact, many researchers stated that none of the alternatives tested have been as efficient as AGP, and in general have given variable results, whereas those obtained with AGP have been consistent and reproducible. Taking into account that it is the reduction of inflammatory bowel edema one of the main theories by which the effect of AGP is explained, it was hypothesized that the use of non-steroidal anti-inflammatory drugs could promote significant reduction of the process inflammatory properties, reducing edema, improving the morphology of intestinal villi and, thus, significantly increasing nutrient absorption, promoting the performance-enhancing effect, which theoretically could be an alternative to the use of AGP. Thus, it is proposed the present project, evaluating the feasibility of the use of these substances, as well as its association with the main currently alternative to AGP, the probiotics. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DI GREGORIO, MAYRA CARRARO; DE ALMEIDA, ELAINE RENATA MOTTA; MOMO, CLAUDIA; ARAUJO, CRISTIANE SOARES DA SILVA; HUEZA, ISIS MACHADO; ANDREO-FILHO, NEWTON; RASPANTINI, LEONILA ESTER REINERT; GOTARDO, ANDRE TADEU; GORNIAK, SILVANA LIMA. Sodium Salicylate as Feed Additive in Broilers: Absence of Toxicopathological Findings. ANIMALS, v. 13, n. 9, p. 13-pg., 2023-04-22. (19/07151-0, 18/19474-6)