Investigation of the action of phenolic extracts in inflammatory bowel diseases: in vitro models for screening of promising residues sources

• Grant number: 18/25107-6
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2019
• End date: April 30, 2021
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Juliana Alves Macedo
• Grantee: Juliana Alves Macedo
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Inflammatory Bowel Disease (IBD) is a disease that affects millions of people in the world, and so far, without curative therapy, and its incidence is growing. IBD encompasses two distinct diseases: Crohn's disease and ulcerative colitis, both of which are characterized by chronic inflammation of the intestine, whose current treatment is based on corticosteroids, immunomodulators, or anti-TNF-±. Such available drugs have serious side effects; therefore the development of new treatment strategies is an important goal in IBD therapy. In addition to the severity of IBD by itself, intestinal inflammation has been linked to the etiology of numerous metabolic disorders and chronic noncommunicable diseases. The development of an in vitro model that mimics intestinal inflammation observed in patients with IBD would allow the study of the potential therapeutic action of large numbers of samples from plants. Numerous studies have demonstrated the anti-inflammatory potential of phenolic compounds, especially flavonoids. In view of the great therapeutic potential that may be being discarded in agroindustrial residues rich in bioactive compounds, the objectives of this project are mainly: the improvement of in vitro models for the study of inflammatory bowel diseases, in order to enable the screening or search for new natural molecules or extracts, without the use of animals, and with high correlation with clinical responses; and the evaluation of the anti-inflammatory potential of some agroindustrial residues rich in flavonoids with some indication of potential action in the modulation of IBD. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARTINS, ISABELA MATEUS; MACEDO, GABRIELA ALVES; MACEDO, JULIANA ALVES. Biotransformed grape pomace as a potential source of anti-inflammatory polyphenolics: Effects in Caco-2 cells. FOOD BIOSCIENCE, v. 35, JUN 2020. (18/25107-6)