| Grant number: | 19/02898-0 |
| Support Opportunities: | Regular Research Grants |
| Start date: | June 01, 2019 |
| End date: | May 31, 2022 |
| Field of knowledge: | Health Sciences - Collective Health - Public Health |
| Agreement: | Leiden University |
| Mobility Program: | SPRINT - Projetos de pesquisa - Mobilidade |
| Principal Investigator: | Thais Mauad |
| Grantee: | Thais Mauad |
| Principal researcher abroad: | Pieter S Hiemstra |
| Institution abroad: | Universiteit Leiden , Netherlands |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| City of the host institution: | São Paulo |
| Associated researchers: | Luís Fernando Amato Lourenço |
| Associated research grant: | 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU), AP.TEM |
Abstract
Plastic products are widely used in society and their degradation products (referred to as microplastics because of their small size) are an increasing cause for societal and scientific concern because of potential adverse effects on the environment and human health. A large number of studies have investigated distribution in water, and effects of microplastics on a range of aquatic organisms. However, microplastics are also present in the air and are inhaled by humans, which may cause adverse effects on the respiratory system. To date, there is limited information on their distribution, size and shape in environmental air samples. In addition, the potential for uptake by lung tissue, and subsequent adverse effects are largely unknown. In this proposal we will bring together researchers from environmental and respiratory sciences, aiming to build technical knowledge and discuss the use of state-of-the-art to detect microplastics in air samples and human lung tissue. In addition, we will address the technical challenges of studying (environmental) microplastic particles on cultured human lung cells. Given that this field or research has only recently emerged, the development and standardization of detection methods of microplastics in both air samples and lung tissue developed in this project will be extremely useful for other experts working in this field. Moreover, analysis of cellular effects will provide key insights into mechanisms of toxicity, and may help to define guidelines for exposure levels. (AU)
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