A randomized, placebo-controlled study evaluating the hemodynamic and metabolic effects of Methylene blue treatment in septic shock

• Grant number: 18/26553-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2019
• End date: November 30, 2022
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Maria Auxiliadora Martins
• Grantee: Maria Auxiliadora Martins
• Host Institution: Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP (HCMRP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto
• Associated researchers: Christiane Becari ; Fábio Luis da Silva ; Mayra Gonçalves Menegueti ; Paulo Roberto Barbosa Evora
• Associated scholarship(s): 21/01195-6 - Evaluation of inflammatory mediators and nitric oxide in plasma of septic patients submitted to treatment with methylene blue, BP.TT

Abstract

Septic shock is the most common cause of death in intensive care unit worldwide and early therapy has been proven to reduce mortality. Despite some recent advances in diagnosis, monitoring and therapy, the mortality rate remains high. It is a life-threatening organ dysfunction due to a dysregulated host response to infection. It is characterized by arterial vasodilation, increased capillary permeability and systemic tissue hypoperfusion, which if not treated rapidly can evolve to multiple organ failure and death. Some review studies, pilot studies and case reports have already shown benefit of the association of methylene blue as a coadjuvant agent for the treatment of vasodilation resulting from septic shock. However, most of these studies were not performed within the first few hours of septic shock. The aim of this study is to determine if the administration of methylene blue in patients in the early stage of septic shock leads to a resolution of shock compared to conventional treatment. This is a randomized placebo-controlled trial with a sample calculation that will show differences in the resolution of septic shock between groups of 30%. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MESTRINER, FABIOLA; FRANCISCO, DANIELY F.; CAMPOS, LIGIA C. B.; COUTO, ARIEL E. S.; FRAGA-SILVA, THAIS F. C.; DUGAICH, VINICIUS FLORA; AVILA-MESQUITA, CAROLINA D.; KOVACS, HENRIQUE ZUKOWSKI; VASCONCELOS, JOCIANY L.; MILANI, ELIZABETE R.; et al. Alpha 1-acid glycoprotein is upregulated in severe COVID-19 patients and decreases neutrophil NETs in SARS-CoV-2 infection. CYTOKINE, v. 176, p. 12-pg., 2024-01-31. (19/21721-4, 23/14949-4, 20/03308-0, 18/23718-8, 18/26553-0, 23/08275-0, 20/05691-5, 19/24369-0, 19/11485-1, 22/13048-0, 21/08796-5, 20/09999-4)

LUIS-SILVA, FABIO; MENEGUETI, MAYRA GONCALVES; SEPEDA, CORINA DOS REIS; PETROSKI-MORAES, BRUNO C.; SATO, LUCAS; PERES, LEANDRO MOREIRA; BECARI, CHRISTIANE; BASILE-FILHO, ANIBAL; EVORA, PAULO R. B.; MARTINS-FILHO, OLINDO ASSIS; et al. ffect of methylene blue on hemodynamic and metabolic response in septic shock patient. MEDICINE, v. 101, n. 3, JAN 21 2022. (18/26553-0)

LUIS-SILVA, FABIO; MENEGUETI, MAYRA GONCALVES; SATO, LUCAS; PERES, LEANDRO MOREIRA; SEPEDA, CORINA DOS REIS; PETROSKI-MORAES, BRUNO C.; DONADEL, MARIANA DERMINIO; GALLO, GABRIELA BORTOLETO; JORDANI, MARIA CECILIA; MESTRINER, FABIOLA; et al. Effect of methylene blue on hemodynamic response in the early phase of septic shock: A case series. MEDICINE, v. 102, n. 4, p. 7-pg., 2023-01-27. (18/26553-0, 17/21539-6, 18/23718-8, 21/01195-6)

LUIS-SILVA, FABIO; MENEGUETI, MAYRA GONCALVES; PERES, LEANDRO MOREIRA; SEPEDA, CORINA DOS REIS; JORDANI, MARIA CECILIA; MESTRINER, FABIOLA; PETROSKI-MORAES, BRUNO CESAR; BRITO-DE-SOUSA, JOAQUIM PEDRO; COSTA-ROCHA, ISMAEL ARTUR; CRUZ, BRUNA LEMOS; et al. Methylene blue therapy in addition to standard treatment for acute-phase septic shock: a pilot randomized controlled trial. FRONTIERS IN MEDICINE, v. 11, p. 10-pg., 2024-10-14. (18/26553-0)

VASCONCELOS, TAUANA FERNANDES; MENEGUETI, MAYRA GONCALVES; CURYLOFO CORSI, CARLOS ALEXANDRE; MICHELON-BARBOSA, JESSYCA; SATO, LUCAS; BASILE-FILHO, ANIBAL; BECARI, CHRISTIANE; SPADOTI DANTAS, ROSANA APARECIDA; AUXILIADORA-MARTINS, MARIA. Assessment of physicians' knowledge about brain death and organ donation and associated factors. MEDICINE, v. 101, n. 38, p. 5-pg., 2022-09-23. (18/26553-0)