Subcutaneous Adipose Tissue Evaluation and its Association with Biomarkers of Inflammation and Energy Metabolism of People Living with HIV / AIDS

• Grant number: 18/21814-0
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2019
• End date: May 31, 2022
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Anderson Marliere Navarro
• Grantee: Anderson Marliere Navarro
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated scholarship(s): 19/21204-0 - Subcutaneous adipose tissue evaluation and its association with biomarkers of inflammation and energy metabolism of people living with HIV / AIDS, BP.TT

Abstract

The effectiveness of antiretroviral therapies (ART) increased the life expectancy of HIV-infected patients. However, ART and HIV itself are associated with changes in adipose tissue biology that affect systemic metabolism and contribute with metabolic and morphologic changes observed in HIV-associated lipodystrophy syndrome (HALS). In addition to its storage function, the adipose tissue also acts as an endocrine organ. Recently researches have shown the role of brown adipose tissue in energy metabolism. Aim: to evaluate the association of brown adipose tissue with biomarkers of inflammation and energetic metabolism in people living with HIV and AIDS with lipodystrophy. Methods: The study will be conducted in Ribeirao Preto Medical School University Hospital. Thirty-three individuals will be evaluate and divided into three groups: 1- HIV-infected people on ART with lipodystrophy; 2- HIV-infected people on ART without lipodystrophy and 3- Healthy people (control). The following variables will be evaluated: brown tissue adipose by computed tomography, body composition by dual emission X-ray absorptiometry (DEXA), resting energy expenditure by indirect calorimetry, and biochemical analysis (glucose and lipid metabolism, adipokines and citokines). Adipose tissue samples of dorsocervical region will be collected and molecular markers of adipogenesis, inflammation, brown fat, and mitochondrial function analysis will be investigated. Statistical tests will be used to assess differences between the groups and the correlations between the variables of interest. (AU)