Modelling the dengue hemorrhagic fever

• Grant number: 19/23202-4
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: December 07, 2019
• End date: December 20, 2019
• Field of knowledge: Physical Sciences and Mathematics - Mathematics - Applied Mathematics
• Principal Investigator: Cláudia Pio Ferreira
• Grantee: Cláudia Pio Ferreira
• Visiting researcher: Maria de Lourdes Esteva
• Visiting researcher institution: Universidad Nacional Autónoma de México (UNAM), Mexico
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

A mathematical model will be set up to describe the temporal evolution of dengue virus and human immune system during a second infection. The hypothesis is that specific and non-especific immunological cells compete by virus neutralization. The goal is to analyse two situation: when the infection is controlled by the immune system; and when the infection is enhanced by the immune cells generated after a primary response with a different virus. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAMARGO, FELIPE DE A.; ADIMY, MOSTAFA; ESTEVA, LOURDES; METAYER, CLEMENCE; FERREIRA, CLAUDIA P.. Modeling the Relationship Between Antibody-Dependent Enhancement and Disease Severity in Secondary Dengue Infection. Bulletin of Mathematical Biology, v. 83, n. 8, AUG 2021. (19/22157-5, 19/23202-4)