Advanced search
Start date

Conjugates of flower pigments and silica: smart and biocompatible hybrid materials


The present proposal aims to develop new smart and biocompatible organic-inorganic hybrid materials from both silica xerogels or aerogels silica containing flower pigments through the collaboration between the research groups of Prof. Fabiano Severo Rodembusch (UFRGS) and Prof. Erick Leite Bastos (USP), who have complementary expertises. The betalamic acid, the betalain precursor, will be obtained biotechnologically from L-DOPA using 4,5-extradiol dioxygenase from isolated or in cellulo Amanita muscaria. Photoresponsive, fluorescent and chelating betalains will be prepared by coupling reaction between betalamic acid and carbon or nitrogen nucleophiles. These compounds will be, in turn, functionalized to the corresponding silyl derivatives using different alkoxysilanes. Betalain-silica xerogels (type I and II) will be prepared by the sol-gel chemistry and their morphological, photophysical and photochemical properties, as well as their interactions with retinal pigment epithelial cells will be studied. These hybrid materials (type I and II) will also be used to prepare new aerogels from CO2 supercritical drying. Also, the effects of lanthanides on the photophysical properties and the potential application of these materials will be investigated. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items