Understanding the molecular bases and the role of risk factors associated to SARS-CoV-2 infection in preclinical models

• Grant number: 20/04746-0
• Support Opportunities: Regular Research Grants
• Duration: April 01, 2020 - May 31, 2022
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal Investigator: Daniel Martins-de-Souza
• Grantee: Daniel Martins-de-Souza
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study, AP.TEM
• Associated scholarship(s): 21/06699-2 - Exploring the molecular basis of SARS-CoV-2 infection in preclinical neural models, BP.PD; 20/10282-7 - Exploring the molecular basis of SARS-CoV-2 infection in preclinical neural models, BP.PD

Abstract

Rapidly, SARS-CoV-2 viral infections became pandemic, leading several countries to a state of public calamity. Using a non-hypothesis driven methodology based on proteomics and metabolomics, the present project aims to identify the molecular mechanisms involved in SARS-CoV-2 infection in macrophage and pulmonary epithelium cultures as well as cultured neurons and astrocytes. We will also investigate preclinical animal models tissue such as brain, lung and bronchoalveolar lavage. We may be able to provide new insights on SARS-CoV-2 infection, which may drive new therapeutic targets, bringing new perspective regarding the spread of the disease and, consequently, provide an improvement in the quality of life of infected individuals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASCOAL, LIVIA BITENCOURT; RODRIGUES, PATRICIA BRITO; GENARO, LIVIA MOREIRA; DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO; TOLEDO-TEIXEIRA, DANIEL AUGUSTO; PARISE, PIERINA LORENCINI; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA LOPES; GUIMARAES, PAULA VERI; BUSCARATTI, LUCAS ILDEFONSO; et al. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. GUT MICROBES, v. 13, n. 1, p. 1-9, JAN 1 2021. (20/04558-0, 20/04583-4, 20/02448-2, 20/02312-3, 19/14342-7, 20/04746-0, 17/26908-0, 20/04579-7, 20/04919-2, 19/06372-3, 13/07607-8, 20/02159-0)