Rapidly, SARS-CoV-2 viral infections became pandemic, leading several countries to a state of public calamity. Using a non-hypothesis driven methodology based on proteomics and metabolomics, the present project aims to identify the molecular mechanisms involved in SARS-CoV-2 infection in macrophage and pulmonary epithelium cultures as well as cultured neurons and astrocytes. We will also investigate preclinical animal models tissue such as brain, lung and bronchoalveolar lavage. We may be able to provide new insights on SARS-CoV-2 infection, which may drive new therapeutic targets, bringing new perspective regarding the spread of the disease and, consequently, provide an improvement in the quality of life of infected individuals. (AU)
Articles published in Agência FAPESP Newsletter about the research grant:
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PASCOAL, LIVIA BITENCOURT;
RODRIGUES, PATRICIA BRITO;
GENARO, LIVIA MOREIRA;
DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO;
TOLEDO-TEIXEIRA, DANIEL AUGUSTO;
PARISE, PIERINA LORENCINI;
SIMEONI, CAMILA LOPES;
GUIMARAES, PAULA VERI;
BUSCARATTI, LUCAS ILDEFONSO;
DE ANGELI ELSTON, JOAO GABRIEL;
SETSUKO AYRIZONO, MARIA DE LOURDES;
VELLOSO, LICIO AUGUSTO;
PROENCA-MODENA, JOSE LUIZ;
MENDES MORAES-VIEIRA, PEDRO MANOEL;
SILVA MORI, MARCELO ALVES;
FARIAS, ALESSANDRO SANTOS;
RAMIREZ VINOLO, MARCO AURELIO;
LEAL, RAQUEL FRANCO.
Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples.
JAN 1 2021.
Web of Science Citations: 9.
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