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Understanding the molecular bases and the role of risk factors associated to SARS-CoV-2 infection in preclinical models


Rapidly, SARS-CoV-2 viral infections became pandemic, leading several countries to a state of public calamity. Using a non-hypothesis driven methodology based on proteomics and metabolomics, the present project aims to identify the molecular mechanisms involved in SARS-CoV-2 infection in macrophage and pulmonary epithelium cultures as well as cultured neurons and astrocytes. We will also investigate preclinical animal models tissue such as brain, lung and bronchoalveolar lavage. We may be able to provide new insights on SARS-CoV-2 infection, which may drive new therapeutic targets, bringing new perspective regarding the spread of the disease and, consequently, provide an improvement in the quality of life of infected individuals. (AU)

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