Natural Deep Eutectic Solvents: synthesis, characterization, and application for the determination of As, Cd, Cr, Hg, Se, and V in environmental samples using ICP-MS

• Grant number: 19/22113-8
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2020
• End date: May 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Mario Henrique Gonzalez
• Grantee: Mario Henrique Gonzalez
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
• Associated researchers: Sabrina dos Santos Ferreira ; Sara Cristina da Silva Cunha

Abstract

The development of sample preparation methods that enable reductions in the use of reagents and solvents, or their replacement, as well as minimal sample handling, the use of more efficient energy sources, and lower risks to the operator and the environment, are all issues addressed by Green Analytical Chemistry (GAC). The use of organic solvents can have serious environmental impacts, so there is an urgent need to develop new alternatives that offer lower toxicity, low cost, and higher safety to the operator. Natural deep eutectic solvents (NADES) are emerging substances that present advantages such as biodegradability, low toxicity, and simple preparation. Methods for the synthesis of new NADES based on amino acids combined with sugars and organic acids will be developed, using a heating and stirring method, evaporation, as well as synthesis assisted by ultrasound (SAU) or microwave radiation (SAM). Characterizations will be performed using techniques including infrared spectroscopy (IV), thermogravimetry (TG), differential exploratory calorimetry (DSC), and measurements of density and viscosity, in order to evaluate the formation of these NADES. After the synthesis and characterization steps, these new solvents will be applied in different green sample preparation methods: extraction at ambient pressure and temperature, microwave-assisted extraction (MAE), and ultrasound-assisted extraction (UAE). In addition, evaluation will be made of synthesis concomitant with the extraction of analytes by the solid phase matrix dispersion (SPMD) technique, applied to environmental matrices and biological tissues. Determination of the potentially toxic elements As, Cd, Cr, Hg, Se, and V will be performed by inductively coupled plasma mass spectrometry (ICP-MS), including a study of the interferences inherent to this analytical technique. Some of the NADES will be evaluated for their ability to extract emerging contaminants such as brominated flame retardants (BRFs) from domestic and industrial sewage sludge samples, with analysis using gas chromatography coupled to mass spectrometry (GC-MS). (AU)

Scientific publications

(16)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, LUANA S.; COSTA, FLORIATAN S.; MACHADO, RAQUEL C.; NOGUEIRA, ANA RITA A.; GONZALEZ, MARIO H.; DA SILVA, ERIK G. P.; AMARAL, CLARICE D. B.. Self-organizing map applied to the choice of internal standards for the determination of Cd, Pb, Sn, and platinum group elements by inductively coupled plasma mass spectrometry. Talanta, v. 233, OCT 1 2021. (19/22113-8, 18/26145-9)

MOREIRA, LUANA S.; SANTANA, ANA P. R.; COSTA, FLORIATAN S.; VERA, JOSIANE B.; GONZALEZ, MARIO H.; DA SILVA, ERIK G. P.; AMARAL, CLARICE D. B.. Enhanced extraction of arsenic and cadmium from environmental samples using a natural deep eutectic solvent and determination by inductively coupled plasma mass spectrometry. INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, v. 102, n. 18, p. 12-pg., 2020-09-29. (14/50945-4, 19/22113-8, 17/18531-3, 15/08873-9)

RIBEIRO MENEZES, IOHANNA M. N.; NASCIMENTO, PATRICIA DE A.; GONZALEZ, MARIO H.; OLIVEIRA, ANDREA. Simple and Robust GFAAS Methods for Determination of As, Cd, and Pb in Hemp Products Using Different Sample Preparation Strategies. FOOD ANALYTICAL METHODS, v. 14, n. 5, JAN 2021. (15/08873-9, 17/18531-3, 19/22113-8)

LAMARCA, RAFAELA S.; FERREIRA, SABRINA DOS S.; PAGANINI, EDER R.; FERREIRA, NATHALIA DOS S.; AYALA-DURAN, SAIDY C.; ISQUIBOLA, GUILHERME; GOMES, PAULO C. F. DE LIMA; AMARAL, CLARICE D. B.; MAGNANI, MARINA; FRANCO, DOUGLAS F.; et al. Sustainable cadmium extraction from sewage sludge samples: A novel approach with hydrophobic deep eutectic solvents and ultrasound-assisted extraction (HDES-UAE) prior to ICP-MS analysis. JOURNAL OF MOLECULAR LIQUIDS, v. 398, p. 9-pg., 2024-02-19. (21/14581-1, 14/50945-4, 21/14759-5, 19/22113-8, 17/18531-3, 23/04832-2)

COSTA, FLORIATAN SANTOS; MOREIRA, LUANA SANTOS; DA SILVA, ERIK GALVA PARANHOS; GONZALEZ, MARIO HENRIQUE; AMARAL, CLARICE D. B.. A greenness evaluation of deep eutectic solvents-based conventional extraction methods for elemental determination by spectrometry techniques. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 174, p. 9-pg., 2024-04-13. (21/14759-5, 19/22113-8)

GUIMARAES, TACIANA G. S.; COSTA, FLORIATAN SANTOS; MENEZES, IOHANNA M. N. R.; SANTANA, ANA P. R.; ANDRADE, DANIEL F.; OLIVEIRA, ANDREA; AMARAL, CLARICE D. B.; GONZALEZ, MARIO H.. Green approaches with amino acids-based deep eutectic solvents (AADES) for determining As in medicinal herbs by ICP-MS. JOURNAL OF MOLECULAR LIQUIDS, v. 381, p. 11-pg., 2023-04-21. (19/22113-8, 16/17304-0, 14/50945-4, 21/14759-5, 17/18531-3)

MOREIRA, LUANA S.; COSTA, FLORIATAN S.; LIDORIO, RITA DE CASSIA; TOLEDO, LUAN W. S.; OLIVEIRA, ANDREA; GONZALEZ, MARIO H.; DA SILVA, ERIK G. P.; AMARAL, CLARICE D. B.. Evaluation of Trace Elements in Marine Biological Tissues by Graphite Furnace Atomic Absorption Spectrometry After Sample Treatment with Formic Acid. FOOD ANALYTICAL METHODS, v. 15, n. 6, p. 8-pg., 2022-03-02. (19/22113-8, 17/18531-3)

GUIMARAES, TACIANA G. S.; ANDRADE, DANIEL F.; SANTANA, ANA P. R.; MOSER, POLIANA; FERREIRA, SABRINA S.; MENEZES, IOHANNA M. N. R.; AMARAL, CLARICE D. B.; OLIVEIRA, ANDREA; GONZALEZ, MARIO H.. Mixture design and physicochemical characterization of amino acid-based DEEP eutectic solvents (AADES) for sample preparation prior to elemental analysis. JOURNAL OF MOLECULAR LIQUIDS, v. 345, JAN 1 2022. (14/50945-4, 15/14488-0, 12/23066-4, 16/17304-0, 19/22113-8)

CALDEIRAO, LUCAS; FERNANDES, JOSE O.; GONZALEZ, MARIO HENRIQUE; GODOY, HELENA TEIXEIRA; CUNHA, SARA C.. A novel dispersive liquid-liquid microextraction using a low density deep eutectic solvent-gas chromatography tandem mass spectrometry for the determination of polycyclic aromatic hydrocarbons in soft drinks. Journal of Chromatography A, v. 1635, JAN 4 2021. (17/18531-3, 17/05048-2, 18/25746-9, 19/22113-8)

COSTA, FLORIATAN SANTOS; MOREIRA, LUANA SANTOS; SILVA, ALISSON MOREIRA; SILVA, RAFAEL J.; DOS SANTOS, MAYARA PADOVAN; DA SILVA, ERIK GALVAO PARANHOS; GRASSI, MARCO TADEU; GONZALEZ, MARIO HENRIQUE; AMARAL, CLARICE D. B.. Natural deep eutectic solvent-based microwave-assisted extraction in the medicinal herb sample preparation and elemental determination by ICP OES. Journal of Food Composition and Analysis, v. 109, p. 8-pg., 2022-03-10. (19/22113-8, 14/50945-4, 17/18531-3)

SANTANA, ANA P. R.; NASCIMENTO, PATRICIA DE ANDRADE; GUIMARAES, TACIANA G. S.; MENEZES, IOHANNA M. N. RIBEIRO; ANDRADE, DANIEL F.; OLIVEIRA, ANDREA; GONZALEZ, MARIO H.. (Re) thinking towards a sustainable analytical chemistry: Part I: Inorganic elemental sample treatment, and Part II: Alternative solvents and extraction techniques. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 152, p. 34-pg., 2022-04-08. (15/08873-9, 19/22113-8, 14/50945-4, 17/18531-3)

COSTA, FLORIATAN SANTOS; MOREIRA, LUANA SANTOS; LUDOVICO, LETICIA LIMA; VOLPE, JAQUELINE; DE OLIVEIRA, ANA CLAUDIA; DOS SANTOS, MAYARA PADOVAN; DA SILVA, ERIK GALVO PARANHOS; SOUTO, DENIO EMANUEL PIRES; GRASSI, MARCO TADEU; GONZALEZ, MARIO HENRIQUE; et al. Microwave-assisted extraction based on emulsion breaking with natural deep eutectic solvent for vegetable oil sample preparation prior to elemental determination by ICP OES. Talanta, v. 266, p. 10-pg., 2023-08-29. (14/50945-4, 21/14759-5, 19/22113-8, 17/18531-3)

BRITO, THOMAS A.; COSTA, FLORIATAN SANTOS; OLIVEIRA, RODOLPHO C.; AMARAL, CLARICE D. B.; LABUTO, GEORGIA; GONZALEZ, MARIO HENRIQUE. Green extraction using natural deep eutectic solvents for determination of As, Cd, and Pb in plant and food matrices by ICP-MS. Food Chemistry, v. 464, p. 11-pg., 2025-02-01. (14/50945-4, 21/14759-5, 19/22113-8, 17/18531-3)

PISHRO, KHATEREH A.; GONZALEZ, MARIO HENRIQUE. Use of deep eutectic solvents in environmentally-friendly dye-sensitized solar cells and their physicochemical properties: a brief review. RSC ADVANCES, v. 14, n. 21, p. 25-pg., 2024-05-02. (14/50945-4, 21/14759-5, 19/22113-8, 17/18531-3)

ANA P. R. SANTANA; DANIEL F. ANDRADE; TACIANA G. S. GUIMARÃES; CLARICE D. B. AMARAL; ANDREA OLIVEIRA; ANA R. A. NOGUEIRA; MARIO H. GONZALEZ. Solventes eutéticos naturais profundos (NADES) no preparo de amostras de rocha fosfática e suplemento mineral para determinação elementar por técnicas de plasma. Química Nova, v. 44, n. 6, p. 689-695, 2021-08-11. (16/17304-0, 17/18531-3, 15/14488-0, 19/22113-8)

FERREIRA, SABRINA S.; BRITO, THOMAS A.; SANTANA, ANA P. R.; GUIMARAES, TACIANA G. S.; LAMARCA, RAFAELA S.; FERREIRA, KAREN C.; GOMES, PAULO C. F. LIMA; OLIVEIRA, ANDREA; AMARAL, CLARICE D. B.; GONZALEZ, MARIO H.. Greenness of procedures using NADES in the preparation of vegetal samples: Comparison of five green metrics. TALANTA OPEN, v. 6, p. 7-pg., 2022-12-01. (21/14581-1, 19/22113-8, 14/50945-4, 15/08873-9, 17/18531-3)